Research Guides

Dr Akane Kawamura

Royal Society Dorothy Hodgkin Research Fellow, BHF Centre of Research Excellence Research Fellow

Chemistry Research Laboratory, University of Oxford
Mansfield Road, Oxford, OX1 3TA, U.K.
Tel: +44 (0)1865 275910 (office) +44 (0)1865 275677 (lab)

Division of Cardiovascular Medicine, Radcliffe Department of Medicine
Wellcome Trust Centre of Human Genetics
Roosevelt Drive, Oxford, OX3 7BN, U.K.
Tel: +44 (0)1865 287831 (office/lab)

Group website:

Williams S, Walport L, Hopkinson R, Madden S, Chowdhury R, Schofield CJ, Kawamura A*. “Studies on the Catalytic Domains of Multiple JmjC Oxygenases Using Peptide Substrates.” Epigenetics 2014 Dec (in press)

Schiller R, Wickens JR, Bush JT, Lejeune C, Choi H, Yeh T-L, Chan MC, Mccullagh JSO, Schofield CJ*, Kawamura A*, “A Cell-Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1” ChemMedChem 2014 9(3):566-71

Hokpkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XL, Kristensen JBL, King ON, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, Lejeune C, Rydzik AM, Rose NR, Bagg EA, Donough MA, Yue WW, Ng SS, Olse L, Brennan P, Oppermann U, Muller-Knapp S, Klose RJ, Ratcliffe PJ, Schofield CJ*, Kawamura A* “5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation” Chemical Science 2013,4, 3110-3117

Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Daniel M, Strain-Damerell C, Gileadi C, Kochan G, Leung IK, Dunford J, Yeoh KK, Ratcliffe PJ, Burgess-Brown N, von Delft F, Muller S, Marsden B, Brennan PE, McDonough MA, Oppermann U, Klose RJ, Schofield CJ*, Kawamura A*. “Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases.” J Med Chem (2012) 55(14) 6639-43.

Kawamura A*, Loenarz C and Schofield CJ* ”Mutations To Metabolic Enzymes In Cancer Herald A Need To Unify Genetics And Biochemistry” Cell Cycle (2011) 10(17):2819-20

Chowdhury R, Yeoh K, Tian Y, Hillringhaus L, Bagg E, Rose NR, Leung IK, Woon EC, Yang M, McDonough MA, King ON, Clifton IJ, Klose RJ, Claridge TD, Ratcliffe PJ, Schofield CJ* and Kawamura A* “The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases” EMBO Reports (2011) 12(5): 463-9

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