Research Guides

 

Research

   John Brown was a Lecturer in Organic Chemistry between 1974 and 2008 following an earlier post at the (brand new) University of Warwick between 1966 and 1974. He was and is a Fellow of Wadham College, now Emeritus. After retirement he held a Leverhulme Emeritus Fellowship for two years and with the initial help from this source continues to be research active through current collaborations, and involvement in non-experimental approaches. He does not recruit students now and does not have his own research space, but would welcome interest  from like-minded chemists.

Previous work

His main long term involvement has been in the catalysis of organic reactions, especially for enantioselective synthesis. He played a part in the emerging area of rhodium asymmetric hydrogenation, helping to unravel the mechanism through the characterization of reactive intermediates (sometimes called the Halpern-Brown mechanism), and contributing to substituent stereocontrol in directed hydrogenations where a stereocentre in the reactant controls the diastereoselection at a new one generated in the reductive step. This led naturally to work on asymmetric hydroboration, and by good fortune the ligand Quinap, designed and synthesized in the research group, proved very effective for this reaction. More recent ventures in catalysis include various studies of palladium catalysed coupling of alkenes (the Heck reaction) including asymmetric couplings, the ruthenium-catalysed reaction, C-H activation studies in arenes and heteroarenes, and perhaps the favourite - the observation of Pd-catalysed methylation of methylation via in internally activated TMS group. The mechanism of Soai's amplifying asymmetric autocatalysis and the structure of the reactive intermediates has been an enduring interest. Much of the emphasis in mechanistic work has been on NMR, as a characterization technique, for the identification of transient intermediates, and in studies of turnover.

Current interests:

Asymmetric catalysis has produced a vast literature and an amazing range of successes. Inevitably, the detailed understanding has lagged behind to a degree, and many groups are now making good the deficit. His work involves both computation and analysis. High level computational methods are routinely accessible now, and can be used by the non-professional. The emphasis is directed towards the ways in which ligand variation can make profound differences to the level of efficiency of catalysis and their role in the underlying recognition processes. A range of simple processes - for example reactions at the borderline of concertedness - are being addressed. The CDS crystallographic database is a superb resource for addressing the relationship between catalyst structure, selectivity and reactivity.

Some molecules and reaction systems:  

    

   

Selected Publications

John M. Brown, Publications to December 2012  1-298 in chronological order

The Metal-Ammonia Reduction of an Allene, J.M. Brown, Chem. and Ind., 1963, 1689.

Proton Magnetic Resonance Spectra of Phenoxide Ions, J.M. Brown, Tetrahedron Letters, 1964,

2215.

Hydroaromatic Steroid Hormones (X).Conversion of Oestrone into Androst-4-ene-3,17-dione, A.J.

Birch, J.M. Brown and G.S.R. Subba Rao, J. Chem., Soc., 1964, 3309.

Reactions of Cyclohexadienones (IV). Transformations of a bis-Dihalocarbene Adduct, A.J. Birch,

J.M. Brown and F. Stansfield, J. Chem. Soc., 1964, 5343.

A New Route to a Cyclooctane Derivative, A.J. Birch, J.M. Brown and F. Stansfield, Chem. and

Ind., 1964, 1917.

Isolation of a cis-1, 2-Divinylcyclopropane, J.M. Brown J. Chem. Soc.Chem. Commun., 1965,

226.

A Non-classical Carbanion, J.M. Brown and J.L. Occolowitz, J.Chem.Soc.Chem.Commun.,

1965, 376.

Antiaromaticity of Cyclopropenyl Anions, R. Breslow, J.M. Brown and J.J. Gajewski, J. Amer.

Chem. Soc., 1967, 89, 4383.

Extensive Delocalisation in Potassium Bicyclo[3.2.1]octadienylide J.M. Brown, J.Chem. Soc.

Chem.. Commun., 1967, 638.

10. Long-range Interactions (I). Enhanced Kinetic Acidity of Bicyclo[3.2.1]octa-2,6-diene,

J.M. Brown and J.L. Occolowitz. J. Chem. Soc., (B) 1968, 411.

Addition of Deuterium Chloride to Norbornene and Norticyclene; a 220 MHz N.m.r. study, J.M.

Brown and M.C. McIvor, Chem. Commun., 1969, 238.

Long-range Interactions, (II). A Model System for p-Interaction between an Allylic Anion and

Olefin, J.M. Brown, J. Chem. Soc.(B) 1969, 868.

Alicyclic Compounds, J.M. Brown, Annual Reports of the Chemical Society 1968: (publ. 1969)

Carbanions and Electrophilic Substitution, J.M. Brown "Organic Reaction Mechanisms, 1968", B.

Capon and C.W. Rees, Ed., John Wiley and Sons, Chichester; (publ 1969)

Thermal Isomerisation of Cyclobutenes (XV). Rates of Isomerisation of exo and endo-Tricyclo

[4.2.1.02,5]nona-3,7-diene and exo- and endo -Tricyclo[4.2.1.02,5]non-3-ene, H.M. Frey, J.

Metcalfe and J.M. Brown, J. Chem. Soc., (B) 1970, 1586.

Stereoselectivity in the Acid Quenching of a non-Classical Carbanion, J.M. Brown and E.N. Cain,

J. Amer. Chem. Soc., 1970, 92, 3821.

Alicyclic Compounds, J.M. Brown, Annual Reports of the Chemical Society 1969; (publ. 1970)

Carbanions and Electrophilic Substitution, J.M. Brown "Organic Reaction Mechanisms, 1969; B.

Capon and C.W. Rees, Ed. John Wiley and Sons, Chichester; (publ. 1970)

Long-range Interactions (III) Comparison of Arene and Olefin as Neighbouring Groups towards

an Allylic Anion, J.M. Brown, E.N. Cain and M.C. McIvor, J. Chem. Soc., B, 1971, 730.

20. Dimethylformamide Dimethylacetal in Methanol Solution. Probable Reversible Formation of

Carbonium Ion and Carbene Intermediates J.M. Brown and B.D. Place J.Chem. Soc.Chem.

Commun., 1971, 533.

A Key Intermediate in Nickel-catalysed Butadiene Dimerisation; its Identity in the Solid and in

Solution, J.M. Brown, B.T. Golding and M.J. Smith, J. Chem. Soc.Chem. Commun., 1971, 1240.

Carbanions and Electrophilic Substitution, J.M. Brown "Organic Reaction Mechanisms, 1970";

B.M. Capon and C.W. Rees, Ed., John Wiley and Sons, Chichester (publ. 1970)

"Mechanism in Organic Chemistry", R.W. Alder, R. Baker and J.M. Brown, John Wiley and Sons,

London. 1971.

Organolithium Reagents in Synthesis; their Modification and Exploitation, J.M. Brown, Chem. and

Ind., 1972, 454.

Carbon Magnetic Resonance Spectra of Representative Organometallic h2-Propene complexes,

K.R. Aris, V. Aris and J.M. Brown, J. Organometal Chem., 1972, 42, C67.

Redirection of the Course of a Cope Rearrangement by Coordination. Thermolysis of (endo-6-

vinylbicyclo[3.1.0]hex-2-ene) rhodium (I) acetylacetonate, V. Aris, J.M. Brown and B.T. Golding,

J. Chem. Soc.Chem. Commun., 1972, 1206.

Thermolysis of Alicyclic Compounds, J. M. Brown MTP Biennial Review of Chemistry; Organic

Chemistry, Volume 4, 1972.

Incipient Chirality in Organometallic Triphenylphosphine Complexes, J.M. Brown and K. Mertis, J.

Organometal Chem., 1973, 47, C5.

Isolation and Characterisation of cis--Divinylcyclopropane J.M Brown, B.T. Golding and J.J.

Stofko, Jr., J. Chem. Soc.Chem. Commun., 1973, 319.

30. Cycloheptatrienerhodium (I) acetylacetonate, J.M. Brown and D.G. Coles, J. Organometal.

Chem.,1973, 60, C31.

Mechanistic Studies on the Course of a h-But-3-enyl to 1-3-h-But-2-enylnickel Transformation,

J.M. Brown and K. Mertis, J. Chem. Soc. Perkin II, 1973, 1993

Relative Ease of Epimerisation of syn-9-Fluoro, syn-9-Methoxy and syn-9-Dimethylaminobicyclo

[6.1.0]nonatriene, J.M. Brown and M.M. Ogilvy J. Amer. Chem. Soc., 1974, 96, 292.

Reactions of Potassium Carbonyl (p-cyclopentadienyl) nickelate with Butenyl and

Cyclopropylmethyl Halides, J.M. Brown, J.A. Conneely and K. Mertis, J. Chem. Soc. Perkin II,

1974, 905.

Synthesis of meso and dl-3,4-Dimethylhexa-1,5-diene and their Acetylacetonatorhodium (I)

Complexes, V. Aris, J.M. Brown and B.T. Golding J. Chem. Soc. Perkin II, 1974, 700.

Ligand Lability in Carbonyl (p-cyclopentadienyl) triphenylphosphineiron Derivatives, K.R. Aris,

J.M. Brown and K.A. Taylor, J. Chem. Soc. Dalton, 1974, 2222.

Structural and Chemical Aspects of Phosphino-ethers as Chelating Ligands in Rhodium (I)

Cationic Complexes. X-Ray Crystal Structures of Two Phosphino-ether Rhodium Carbonyl

Complexes, N.W. Alcock, J.M. Brown and J.C. Jeffery, J. Chem. Soc.Chem. Commun.,

1974, 829.

Stereoselective Micelle-Promoted Ester Hydrolysis, J.M.Brown and C.A. Bunton, J. Chem.

Soc.Chem. Commun., 1974, 969.

Micellar General Base-catalysed Hydrolysis of Diphenyl p-Nitrophenyl Phosphate, J.M. Brown,

C.A. Bunton and S. Diaz, J. Chem. Soc.Chem. Commun., 1974, 971.

Synthesis and Thermolysis of Rhodium and Iridium Complexes of endo-6-Vinylbicyclo[3.1.0]

hex-2-ene. A Metal-promoted Vinylcyclopropane to Cyclopentene Rearrangement, V. Aris,

J.M. Brown, J.A. Conneely, B.T. Golding and D.H. Williamson, J. Chem. Soc. Perkin II, 1975, 4.

Organorhodium Complexes of cis -and trans-Divinylcyclopropane. The Crystal Structure of ZZ-

1,2,3-h-5,6,7-h-Heptadienediylrhodium (I) hexafluoroacetylacetonate, N.W. Alcock, J.M. Brown,

J.A. Conneely and J.J. Stofko, Jr. J. Chem. Soc.Chem. Commun., 1975, 234.

Localised Regions of Reduced Mobility in Micelles; 13C N.m.r. Spin-lattice Relaxation Times of

Functional Surfactants in Aqueous Solution, J.M. Brown and J.D. Schofield, J. Chem. Soc.Chem.

Comm., 1975, 434.

Reactive Rhodium Complexes Derived from trans-6-Vinylbicyclo[3.1.0]hex-2-ene. Mechanistic

Studies and X-ray Structure of h3,1-3-(4-Allylcyclopent-1-enyl) hexafluoroacetylacetonato

rhodium Tetramer, N.W. Alcock, J.M. Brown, J.A. Conneely and D.H. Williamson, J. Chem. Soc.

Chem.Commun., 1975, 792.

Rhodium Phosphinoether Complexes. Part 1. Crystal and Molecular Structures of trans [1,5-

Bis(diphenylphosphino)-3-oxapentane-O,P,P] carbonylrhodium (I) Hexafluorophosphate and

trans-Aqua [1,11]-Bis (diphenylphosphino)-3,6,9-trioxaundecane-P,P'] carbonylrhodium (I)

Hexafluoro phosphate. N.W. Alcock, J.M. Brown and J.C. Jeffery, J. Chem. Soc. Dalton, 1976,

583.

Micelle-related Heterogeneous Catalysis. Anion Activation by Polymer-linked Cationic

Surfactants, J.M. Brown and J.A. Jenkins, J. Chem. Soc.Chem. Commun., 1976, 456.

An Assessment of the Mobility of Squalene in Part-Aqueous Solutions from Carbon Magnetic

Resonance Spin-Lattice Relaxation Times. Comparison with Squalene and 2,3-Dihydroxy-2-3-

dihydrosqualene, J.M. Brown and D.R.M. Martens, Tetrahedron, 1977, 33, 931.

Rhodium Phosphinoether Complexes, Part 2. Crystal and Molecular Structures of trans [1,8-

Bis(diphenylphosphino)-3,6-dioxaoctane-P,P'] carbonyl(ethanol)rhodium (I) Hexafluorophosphate

and trans- 1,5-Bis (diphenylphosphino)-3-oxapentane-P,P' carbonyl chlororhodium(I) Dimer, N.W.

Alcock, J.M. Brown and J.C. Jeffery, J. Chem. Soc. Dalton 1977, 888.

Strong Amide-Halothane Hydrogen-bonding observed by Nuclear Magnetic Resonance, J.M.

Brown and P.A. Chaloner, Canad. J. Chem., 1977, 55, 3380.

Selective Homogeneous and Heterogeneous Catalysis, J.M. Brown, Ciba Symposium 53 "Further

Perspectives in Organic Chemistry", 1978, 149.

Mechanism of Asymmetric Hydrogenation Catalysed by Rhodium (I) trans-4,5-Bis

(diphenylphosphinomethyl)-2,2-dimethyldioxolan (DIOP) Complexes. J.M. Brown and P.A.

Chaloner, J. Chem. Soc.Chem. Commun., 1978, 321.

50. Mechanism of Asymmetric Hydrogenation Catalysed by Rhodium (I) DIPAMP complexes, J.M.

Brown and P.A. Chaloner, Tetrahedron Letters, 1978,19, 1877.

cis-Divinylcyclopropane and the Hexafluoroacetylacetonatorhodium Complexes of cis- and trans-

Divinylcyclopropane, J.M. Brown, B.T. Golding and J.J. Stofko, Jr., J. Chem. Soc. Perkin II, 1978,

436.

Diversity of Behaviour of Bicyclo[2.2.1]heptadiene-bis-Phosphine Complexes on Hydrogenation in

Methanol, J.M. Brown, P.A. Chaloner and P.N. Nicholson, J. Chem. Soc.Chem. Commun., 1978,

646.

Enantiomer Recognition and Conformational Equilibria in Platinum [0] Complexes of 2,3-

Isopropylidene-2,3-trans-dihydroxy-1,4-bis(diphenylphosphino) butane, (DIOP) J.M. Brown and

P.A. Chaloner, J. Amer. Chem. Soc.,1978, 100, 4307.

Acyl-transfer Reactions in Functional Micelles studied by Proton Magnetic Resonance, J.M.

Brown, P.A. Chaloner and A. Colens, J. Chem. Soc. Perkin II, 1979, 71.

Hydrophobic Effects in the Micellar Reactions of Peroxide Nucleophiles, J.M. Brown and J.R.

Darwent J. Chem. Soc.Chem. Commun., 1979, 169.

Proximity Effects in the Reactions of Surfactant p-Nitrophenyl Esters with Peroxide Nucleophiles,

J.M. Brown and J.R. Darwent, J. Chem. Soc.Chem. Commun., 1979, 171.

Synthesis of trans-4,5-Bis(diphenylarsinomethyl)-2,2-dimethyl-1,3-dioxolan and an Improved

Preparation of its Phosphine Analogue (DIOP). B.A. Murrer, J.M. Brown, P.A. Chaloner, P.N.

Nicholson and D. Parker, Synthesis, 1979, 350.

Further Studies on Metal-promoted Vinylcyclopropane to Cyclopentene Rearrangements.

Structure and Thermolysis of Rhodium Complexes of exo-6-Vinylbicyclo[3.1.0]hex-2-ene and

Crystal Structure of 1,6-8, h4-5-Allylcyclopent-2-enyl(hexafluoroacetylacetonato) rhodium (III)

Tetramer. N.W. Alcock, J.M. Brown, J.A. Conneely and D.H. Williamson, J. Chem. Soc. Perkin II,

1979, 962.

R-Phenyl-bis-diphenylphosphinoethane; Structural Studies pertaining to Rhodium-catalysed

Asymmetric Hydrogenation. J.M. Brown and B.A. Murrer, Tetrahedron Letters, 1979, 20, 485-9.

60. Structure and Reactivity in Micellar Aggregates, J.M. Brown, SPR Colloid Science, 1979, 3, 253.

Asymmetric Homogeneous Hydrogenation catalysed by Rhodium Complexes; the Binding Modes

of Enamides defined by 13C N.m.r. Spectroscopy, J.M. Brown and P.A. Chaloner, J. Chem. Soc.

Chem.Commun., 1979, 613.

Asymmetric Hydrogenation catalysed by Rhodium Complexes of 2R 4R-bis(diphenylphosphino)

dioxolan. A Stable Rhodium Dihydride derived from a Chelating Diphosphine Complex, J.M.

Brown, P.A. Chaloner, C. Descotes, D. Lafont and D. Sinou, J. Chem. Soc. Chem. Commun.,

1979, 611.

Supported Rhodium-phosphine Hydrogenation Catalysts of High Mobility and Reactivity, J. M.

Brown and H. Molinari, Tetrahedron Letters, 1979, 20, 2933.

Oxocarboxylic Acids, J.M. Brown "Comprehensive Organic Chemistry", Volume 2, Ch 9:5 pg 779

ff, D.H.R. Barton and W.D. Ollis, Ed., Pergamon Press 1979.

Reversal of Chirality induced by Ortho-Methoxyl Substitution of Arylphosphine Ligands in

Rhodium-Catalysed Asymmetric Hydrogenation, J.M. Brown and B.A. Murrer, Tetrahedron Letters,

1980, 21, 581

Intermediates in Asymmetric Hydrogenation. The Structure and 31P NMR Spectra of Rhodium

Enamide Complexes containing 1R, 2R-Trans-1,2-Bis (Diphenylphosphinomethyl) Cyclobutane'

J.M. Brown, P.A. Chaloner, R. Glaser and S. Geresh Tetrahedron, 1980, 36, 815.

 

Micellar Catalysis, J.M. Brown, S.K. Barker, A. Colens, and J.R. Darwent in 'Enzymic and Non-

Enzymic Catalysis' Chapter 5, pg 111 ff.; P. Dunnill, A. Wiseman and N. Blakebrough, Eds. Ellis

Horwood, Chichester, 1980.

'Rational Approaches to Asymmetric Hydrogenation' J.M. Brown, P.A. Chaloner, B.A. Murrer, and

D. Parker., A.C.S. Symposium Series, 1980, 119, 169.

The Mechanism of Asymmetric Homogeneous Hydrogenation. Rhodium (I) Complexes of

Dehydroamino Acids containing Asymmetric Ligands related to Bis (1,2-

diphenylphosphino)ethane' J.M. Brown and P.A. Chaloner, J. Am. Chem. Soc., 1980, 102, 3040.

70. Structural and Catalytic Aspects of Functional Micelles. Ester Hydrolysis by Hydroxamic Acids

bound to Cationic Surfactants, J.M. Brown and J.L. Lynn, Jr., Ber. Bunsenges Phys. Chem., 1980,

84, 95.

Intermediates in the Asymmetric Hydrogenation of Unsaturated Carboxylic Acid Derivatives, J.M.

Brown and D. Parker, J.Chem.Soc. Chem. Commun., 1980, 342.

Structural Characterisation of a Transient Intermediate in Rhodium-catalysed Asymmetric

Homogeneous Hydrogenation, J.M. Brown and P.A. Chaloner, J.Chem.Soc. Chem. Commun.,

1980, 344.

Dephosphorylation in Functional Micelles. The Role of the Imidazole Group, J.M. Brown, C.A.

Bunton, S. Diaz and Y. Ihara, J. Org. Chem., 1980, 45, 4169.

Further Studies on Asymmetric Hydrogenation by Rhodium Complexes of 2R, 4R

bis(diphenylphosphineomethyl)dioxolane, G. Descotes, D. Lafont, D. Sinou, J.M. Brown and P.A.

Chaloner, Nouv. J. Chem., 1981, 5, 167.

The Proton Magnetic Resonance Spectrum of Amphotericin B, J.M. Brown and P.J. Sidebottom

Tetrahedron, 1981, 37, 1421.

Determination of Optical Purity at Isotopically Chiral Sites by 2H NMR. J.M. Brown and D. Parker,

Tetrahedron Letters, 1981, 22, 2815.

The Mechanism of Asymmetric Homogeneous Hydrogenation. Solvent Complexes and Dihydrides

from Rhodium Diphosphine Precursors. J.M. Brown, P.A. Chaloner, A.G. Kent, B.A. Murrer, P.N.

Nicholson. D. Parker and P.J. Sidebottom, J. Organometal Chem., 1981, 216, 263.

Structural Specificity in Asymmetric Charge-transfer Complexation of Helicenes, J.M. Brown, I.P.

Field and P.J. Sidebottom, Tetrahedron Letters, 1981, 22, 4867.

Conformational Dynamics of Azacyclotridecan-2-ones; trans-Lactam Racemisation in Competition

with Amide Rotation, J.M. Brown, P.A. Chaloner and D.R.M. Martens, J. Chem. Research (S)

1981, 380.

80. Selective Micellar Catalysis with Histidinyl Surfactants of Defined Absolute Configuration, J.M.

Brown, R.L. Elliott, C.G. Griggs, G. Helmchen and G. Nill, Angew. Chem. Int. Ed., 1981, 20, 890.

Mechanistic Studies of Rhodium-Catalysed Asymmetric Homogeneous Hydrogenation. J.M.

Brown, P.A. Chaloner and D. Parker, A.C.S. Advances in Chemistry Series, 1982, 196, 355.

Chelate Control in the Rhodium-catalysed Homogeneous Hydrogenation of Chiral Allylic and

Homoallylic Alcohols, J.M. Brown and R.G. Naik, J. Chem. Soc. Chem. Commun., 1982, 348.

Ab initio Molecular Orbital Calculations on Allylic Anion-Olefin Interactions, J.M. Brown, R.J. Elliott

and W.G. Richards, J. Chem. Soc. Perkin II, 1982, 485.

The Mechanism of Asymmetric Homogeneous Hydrogenation. Chiral bis (diphenylphosphino)

-a-phenylalkane Complexes in Catalytic and Structural Studies, J.M. Brown and B.A. Murrer, J.

Chem. Soc. Perkin II, 1982, 489.

The Mechanism of Asymmetric Homogeneous Hydrogenation. Rhodium Complexes formed by

Dehydroamino Acids Co-complexed with trans-4,5-Bisdiphenylphosphino-2,2-dimethyldioxolan

and Achiral Models, J.M. Brown and P.A. Chaloner, J. Chem. Soc. Perkin II, 1982, 711

Observation of Dicarbonyldiphosphinerhodium Hydrides and their Olefin Trapping Ability, J.M.

Brown, L.R. Canning, A.G. Kent and P.J.Sidebottom, J. Chem. Soc. Chem. Commun., 1982, 721.

Structure and Dynamics of the Stable Rhodium-acyl complex formed during Hydroformylation,

J.M. Brown and A.G. Kent, J. Chem. Soc. Chem. Commun., 1982, 723.

Site-Specific and Random Degenerate Rearrangements in h6 and h4-Cycloheptatriene Metal

Complexes, J.M. Brown, I. Midgley and W.J. Albery, J. Chem. Soc. Perkin II, 1982, 767.

Mechanism of Asymmetric Hydrogenation. Rhodium Complexes formed by Unsaturated

Carboxylic Acids, Carboxylates and Carboxamides, J.M. Brown and D. Parker, J. Org. Chem.,

1982, 47, 2722.

90. Mechanism of Asymmetric Homogeneous Hydrogenation. Rhodium-catalysed Reductions with

Deuterium and Hydrogen Deuteride, J.M. Brown and D. Parker Organometallics, 1982, 1, 950.

Reactivity and Selectivity in Catalysis by Organorhodium Complexes, J.M. Brown, Chem and Ind.,

1982, 737.

Micellar Structure and Catalysis, J.M. Brown and R.L. Elliott, Chemical Society S.P.R.Colloid

Science, 1983, 4, 180.

Kinetic and Thermodynamic Control in the reaction of (Ph3P)2 PtO2 with E-2-Butenal, M.J.

Broadhurst, J.M. Brown and R.A. John, Angew. Chem. Int. Ed., 1983, 22, 47.

Interconversion of cis and trans-Dihydrides derived from Chelate Biphosphine Complexes, J.M.

Brown, F.M. Dayrit and D. Lightowler, J. Chem. Soc. Chem. Commun., 1983, 414.

Rhodium Complexes of 2,5-bis-Diphenylphosphinofuran; a Ligand Selective for Binuclear

Chelation, J.M. Brown and L.R. Canning, J. Chem. Soc. Chem. Commun., 1983, 460.

Identification of a Further Transient Species relationg to Rhodium Complex Catalysed Asymmetric

Hydrogenation, J.M. Brown, P.A. Chaloner and G.A. Morris, J. Chem. Soc. Chem. Commun.,

1983, 664.

Asymmetric Hydrogenation Reactions using Chiral Diphosphine Complexes of Rhodium, J.M.

Brown and P.A. Chaloner, "Homogeneous Catalysis with Metal-Phosphine Complexes", L.H.

Pignolet, Ed. Plenum Press, 1984, pg 137 ff.

Equilibration of ortho and para-Hydrogen by Homogeneous Hydrogenation Catalysts in Solution; a

Test for the Reversibility of Hydrogen Addition, J.M. Brown, L.R. Canning, A.J. Downs and A.M.

Forster. J. Organometallic Chem., 1983, 255, 103.

Scope and Limitations of the Stereoselective Homogeneous Hydrogenation of

Methylenecyclohexanols by Cationic Rhodium Complexes, J.M. Brown and S.A. Hall, Tetrahedron

Letters, 1984, 25, 1393.

100. Mono- and Dinuclear Complexes of meso- and dl-1,1,4,7,10,10-hexaphenyl-1,4,7,10-tetra

phosphadecane. Stereochemical Control of Reactivity and Complexation Geometry, J.M. Brown

and L.R. Canning, J. Organometal Chem., 1984, 267, 179.

A Simple Route to bb-Trehalose via Trichloroacetimidate Coupling, J.M. Brown, S.J. Cook and R.

Khan, J. Carbohyd. Chem., 1984, 3, 343.

Olefin Displacement from 4,5-bis (diphenylphosphinomethyl) 2,2-dimethyl-1,3-

dioxolanethyleneplatinum [0] under mild conditions, J.M. Brown, S.J. Cook and S.J. Kimber, J.

Organometal Chem., 1984, 269, C58.

On the Accessibility of cis-Biphosphine Intermediates in Homogeneous Hydrogenation by

Wilkinson's Complex, ClRh(PPh3)3, J.M. Brown and A.R. Lucy, J. Chem. Soc. Chem. Comm.,

1984, 914.

Contrasting Reactivity of Mono- and Dinuclear Dihydro-trans-Biphosphine Rhodium and Iridium

Complexes towards Alkenes, J.M. Brown, L.R. Canning and A.R. Lucy, J. Chem. Soc. Chem.

Commun., 1984, 915.

High Stereo- and Regioselectivity in the Reaction of 1,2-Bis(dimethylphosphino~

ethane)hydridomethylplatinum with p-Chlorophenyl Isonitrile, N.W. Alcock, J.M. Brown and T.D.

McLean, J. Chem. Soc. Chem. Commun., 1984, 1689.

Observations on Olefin Oxidation by Neutral and Cationic Phosphineiridium Complexes, J.M.

Brown, R.A. John and A.R. Lucy, J. Organometallic Chem., 1985, 279, 245. (J.Halpern 60th

birthday issue).

Association of Alkali-metal Salts with Polyene Macrolides in Methanol Solution, J.M. Brown, A.E.

Derome and S.J. Kimber, Tetrahedron Letters, 1985,26, 253.

Stereochemical Control by Carboxylate Groups in Homogeneous Hydrogenation, J.M. Brown and

S.A. Hall, J. Organometal Chem., 1985, 285, 333.

Iridium Analogues of Catalytic Intermediates in Asymmetric Hydrogenation, N.W. Alcock, J.M.

Brown, A.E. Derome and A.R. Lucy, J. Chem. Soc. Chem. Commun., 1985, 575.

110. Effective Kinetic Resolution in the Asymmetric Hydrogenation of a-(Hydroxyalkyl) acrylate Esters,

J.M. Brown and I. Cutting, J. Chem. Soc. Chem. Commun., 1985, 578.

Allylic Alkylation Catalysed by Platinum Complexes; Structure and Reactivity of Intermediates and

the Overall Stereoselectivity, J.M. Brown and J.E. MacIntyre J. Chem. Soc. Perkin II, 1985, 961.

External and Internal Asymmetric Induction in Homogeneous Hydrogenation, J.M. Brown, S.A.

Hall and A.R. Lucy, "Metal Complex Catalysis.2" pp 7-26, H. Pracejus, Ed. GDR Academy of

Sciences,, Rostock, 1985.

Comparison of Cationic Rhodium and Iridium Complexes in Directed Homogeneous

Hydrogenation, J.M. Brown and S.A. Hall, Tetrahedron, 1985, 41, 4639.

Nature of the Catalytic Cycle in Iridium-Complex Catalysed Hydrogenation of Unsaturated

Alcohols, J.M. Brown, A.E. Derome and S.A. Hall, Tetrahedron, 1985, 41, 4647.

Factors Affecting Stereochemical Control in Directed Homogeneous Hydrogenation of a-

Hydroxyalkylacrylates, J.M. Brown, I. Cutting, P.L. Evans and P.J. Maddox, Tetrahedron Letters,

1986, 27, 3307.

Stereoselectivity in the Hydroboration of Chiral Cyclohexane-derived allylic alcohols, D.H.

Birtwistle, J.M. Brown and M.W. Foxton, Tetrahedron Letters, 1986, 27, 4367.

trans-Bis(Diphenylphosphino)cyclopropane; a Ligand Selective for Binuclear Complexation with

ca. 4.5 A Intermetallic Separation, J.M. Brown and A.R. Lucy, J. Organometal Chem., 1986, 314,

241.

Structural Comparison of Trehalose Anomers; The X-Ray Crystal Structures of aa-(2,3,4-Tri-0-

Methyl-6-Methanesulphonyl)Glucopyranosyl-1-0-(2',3',4'Tri-0-Methyl-6'-

Methanesulphonyl)Glucopyranose, and its bb-isomer. J.M. Brown, S.J. Cook, R.H. Jones and R.

Khan, Tetrahedron, 1986, 42, 5089.

Flexible Cis- or Trans- Chelating Biphosphine Ligands Derived from aa- or bb-Trehalose J.M.

Brown, S.J. Cook and A.G. Kent, Tetrahedron, 1986, 42, 5097.

Hydroformylation Catalysed by Rhodium Complexes of Trehalose-Derived Ligands aa- and bb-

TREDIP; A Highly Regioselective Route To a-Methylarylpropionaldehydes, J. M. Brown, S. J.

Cook, and R. Khan, Tetrahedron, 1986, 42, 5105.

Substrate-induced Kinetic Resolution of Racemic Biphosphines in situ for Homogeneous

Catalysis; N.W. Alcock, J.M. Brown and P.J. Maddox, J. Chem. Soc. Chem. Commun., 1986,

1532.

Stereoselective Homogeneous Hydrogenation of 3-Substituted Itaconate Esters, J.M. Brown and

A.P. James, J. Chem. Soc. Chem. Commun., 1987, 181.

Chiral Ligands for Organometallic Catalysis containing two Dioxolane Rings, J.M. Brown, F.M.

Dayrit and D. Sinou, J. Chem. Soc. Perkin II, 1987, 92.

Directed Homogeneous Hydrogenation, J.M. Brown, Angew. Chem. Int. Ed., 1987, 26, 190.

The Catalytic Resting State of Asymmetric Homogeneous Hydrogen. ExchangeProcesses

delineated by N.m.r. Saturation-transfer (DANTE) Techniques, J.M. Brown, P.A. Chaloner and

G.A. Morris, J. Chem. Soc. Perkin II, 1987, 1583.

Stereochemistry of Intermediates in Homogeneous Hydrogenation Catalysed by ClRh(PPh3)3,

employing N.m.r. Magnetisation Transfer, J.M. Brown, P.L. Evans and A.R. Lucy, J. Chem. Soc.

Perkin II,1987, 1589.

Structural Characterisation in Solution of Intermediates in Rhodium-catalysed Hydroformylation

and Interconversion Pathways, J.M.Brown and A.G.Kent, J. Chem. Soc. Perkin II 1987, 1597.

Kinetic Resolution in the Directed Hydrogenation of N-substituted a-(Aminoalkyl)acrylates,

Precursors of Optically Active b-Aminoacids, J.M. Brown, A.P. James and L.M. Prior, Tetrahedron

Letters, 1987, 28, 2179.

Platinum-Metal Complexes in Asymmetric Catalysis, J.M.Brown, Platinum Met. Rev, 1987, 31,

137.

130. Solution Structures of Iridium Alkyl Hydrides Pertaining to Asymmetric Hydrogenation, J.M. Brown

and P.J. Maddox, J. Chem. Soc., Chem. Commun., 1987, 1276.

Hydrogen Transfer and C-H Activation in a Dihydroiridium Amido-alkene Complex, J.M. Brown

and P.J. Maddox, J. Chem. Soc., Chem. Commun., 1987, 1278.

Stereoselective Homogeneous Hydrogenation. The Basis of Preferential anti-Isomer Formation in

Acyclic Systems, J.M. Brown, I. Cutting and A.P. James, Bull. Soc. Chim.France, 1988, 211.

Structure and Reactivity in Asymmetric Hydrogenation; A Molecular Graphics Analysis, J.M.

Brown and P.L. Evans, Tetrahedron, 1988, 44, 4905.

Geminally l3C-Labelled Vinyl Iodides. E-2'-Iodo-4-methoxyphenyl [2-l3C]ethene from [l3C]-

Iodoform, K.V. Baker, J.M. Brown and N.A. Cooley, J. Labelled Comp. and Radiopharm. 1988,

XXV, 1229.

Carbon-carbon Bond Formation through Organometallic Elimination Reactions, J.M. Brown and

N.A. Cooley, Chem. Rev., 1988, 88, 1031.

Transient and Stable Intermediates in Cross-coupling Reactions, J.M. Brown and N.A. Cooley,

Phil. Trans. R. Soc. Lond. A. 1988, 326, 587.

Catalytic Kinetic Resolution, J.M. Brown, Chem. and Ind., 1988, 612.

Directed Homogeneous Hydrogenation, anti Methyl 3-hydroxy-2-methylpentanoate, J.M. Brown,

P.L. Evans and A.P. James Organic Syntheses, 1989, 68, 64

Phosphinosulphoxide Rhodium Complexes. Synthesis, Structure and Catalytic Chemistry of

[(2,3,5,6-h)Bicyclo[2.2.1]heptadiene][P,O-diphenyl-(phenylsulphinylmethyl)phospine]-rhodium (I)

tetrafluoro borate, and Asymmetric Analogues, N.W. Alcock, J.M. Brown and P.L. Evans, J.

Organomet. Chem., 1988, 356, 333

140. Stereochemical Course of Hydrogen Addition to Bis (SS) 2-3-bis(diphenylphosphino) butane

iridium (I) tetrafluoroborate, J.M. Brown, P.L. Evans, P.J. Maddox and K.H. Sutton, J. Organomet.

Chem., 1989, 359, 115.

Observation of Stable and Transient Intermediates in Palladium-catalysed Cross-coupling

Reactions, J.M. Brown and N.A. Cooley, J. Chem. Soc. Chem. Commun., 1988, 1345.

Mono- and Binuclear Complexes of the Rigid Bidentate Ligand 2-Ethylthio-5-

diphenylphosphinofuran, M. Bressan A. Morvillo and J.M. Brown,

J. Organomet. Chem.,1989, 361, 249.

Structure of the Rhodium Complex of a Reactant in Directed Hydrogenation, N.W. Alcock, J.M.

Brown and A.P. James, Acta Cryst. C, 1989, 45, 734.

Diastereoselectivity in the Intramolecular Diels-Alder Reaction of Dienylpropynoates, D.H.

Birtwistle, J.M. Brown, and M.W. Foxton, Tetrahedron, 1988, 44, 7309.

Conformational Analysis of the Directed Hydrogenation of Homoallylic Alcohols, D.H. Birtwistle,

J.M. Brown, R.H. Herbert, A.P. James, K-F. Lee and R.J. Taylor, J. Chem. Soc. Chem. Commun.,

1989, 194.

Arylation of Alkenyl Bromides catalysed by Platinum Complexes, J.M. Brown, N.A. Cooley and

D.W. Price, J. Chem. Soc. Chem. Commun., 1989, 458.

Reactive Intermediates in Asymmetric Cross-Coupling Catalysed by Palladium P-N Chelates,

K.V. Baker, J.M. Brown, N.A. Cooley, G.D. Hughes and R.J. Taylor, J. Organometal Chem.,

1989, 370, 397. ( Metal Chirality Special Issue)

Enantiomerically Pure Compounds; Meeting the Synthetic Challenge, S.G. Davies, J.M. Brown,

A.J. Pratt, and G.W.J. Fleet, Chemistry in Britain 1989, 259.

Asymmetric Homogeneous Catalysis, J.M. Brown, Chemistry in Britain, 1989, 276.

150. Chemical Asymmetric Synthesis, J.M. Brown and S.G. Davies, Nature, 1989, 342, 631; (Nature

(Scientific Correspondence) 1990, 345, 582)

On the Strain Energies of 5-Ring and 6-Ring Lactones, J.M. Brown, A.D. Conn, G. Pilcher, M.L.P.

Leitao and Y. Meng-Yann, J. Chem. Soc. Chem. Commun., 1989, 1817.

Mapping the Reaction Pathway in Palladium-Catalysed Cross-Coupling Reactions, J.M. Brown

and N.A. Cooley, Organometallics, 1990, 9, 353.

The Nucleophilic Displacement Route to Homochiral Phosphine Oxides, J.M. Brown, J.V. Carey

and M.J.H. Russell, Tetrahedron, 1990, 46, 4877. (W.D.Ollis 65th birthday issue)

Catalytic Asymmetric Hydroboration with Oxazaborolidines, J.M. Brown and G.C. Lloyd-Jones,

Tetrahedron Asymmetry, 1990, 1, 869.

Enthalpies of Combustion of g -Butyrolactone, g-Valerolactone and d-Valerolactone M.L.P. Leitao,

G. Pilcher, M-Y Yang, J.M. Brown and A.D. Conn, J. Chem. Therm., 1990, 22, 885.

Mechanical Activation of Magnesium Turnings for Preparation of Reactive Grignard Reagents,

K.V. Baker, J. M. Brown, N. Hughes, A.J. Skarnulis and A. Sexton J. Org. Chem, 1991, 56, 698.

Control Factors for Selective Homogeneous Catalysis, J.M. Brown, J.V. Carey, A.D. Conn, G.C.

Lloyd-Jones and S.C. Woodward, "Advances in Catalyst Design"; M. Graziani and C.N. R. Rao,

Eds, World Scientific Press, 1991, pg 299 ff. (Proceedings of the Workshop on Catalyst

Design, Trieste, Dec 1990).

The Carbon-Carbon Bond forming Step in Catalytic Cross-coupling; Migration or Elimination? M.J.

Calhorda, J.M. Brown and N.A. Cooley Organometallics, 1991, 10, 1431

A Simple General Route to Chelate Diphosphine Ruthenium (II) Complexes, N.W. Alcock, J.M.

Brown, M. Rose and A. Wienand, Tetrahedron Asymmetry, 1991, 2, 47.

160. Synthesis with a Strong Hand, J.M. Brown, Nature, 1991, 350, 191. (News and Views)

Enantioselective Catalytic Transfer Hydrogenation of ab-Unsaturated Carboxylic Acids with

Formates Catalysed by Novel Ruthenium Phosphine Complexes, J.M. Brown, H. Brunner, W.

Leitner and M. Rose Tetrahedron Asymmetry, 1991, 2, 331.

Iridium Complexes of Dehydroamino Acids; the Kinetic Resolution of Racemic Diphosphines and

their Application in Catalytic Asymmetric Hydrogenation, J.M. Brown and P.J. Maddox, Chirality,

1991, 3, 345 [ s.a.1992, 4, 71]. (P.Pino memorial volume).

Selective ortho-Lithiation of [2,5-Dimethoxyphenyl)diphenylphosphine oxide and Trapping of the

Resulting Lithium Aryl with Electrophiles, J.M. Brown and S.C. Woodward, J. Org. Chem., 1991,

56, 6803.

Solid-state Conformations of Six 1,3,2-Oxazaphospholidinones derived from (-)-Ephedrine:

X-Ray Crystal Structures of the 2-Phenoxy-2-oxo, 2-Phenyl-2-oxo and 2-Phenyl-2-thio

Analogues, G.Chopra, S. Freeman, C.H.Schwalbe, J.M. Brown and J.V. Carey,

J. Chem. Soc. Perkin II, 1991, 2081.

Homogeneous Hydrogenation with Iridium Complexes. Evidence for Polyhydride Intermediates in

the Reduction of a-Pinene, J.M. Brown, A.E. Derome, G.D. Hughes and P.K. Monaghan, Aust J.

Chem 1992, 45, 143 (A.J. Birch 75th Birthday issue).

Synthesis and Racemisation of an Atropisomerically Chiral Phosphinamine, N.W. Alcock, J.M.

Brown, M. Pearson and S. Woodward,Tetrahedron :Asymmetry 1992, 3, 17.

Restricted Rotation in cis-Diphosphine Arylplatinum Complexes, N.W. Alcock, J.M. Brown and J.J.

Pérez-Torrente, Tetrahedron Lett. 1992, 33, 389

A Rapid Assay for the Enantiomeric Purity of Secondary Alcohols using 4S,5R-4-methyl,5-phenyl-

1,3,2-oxazaborolidine (Ephedrineborane), J.M. Brown, S.W. Leppard and G.C. Lloyd-Jones,

Tetrahedron :Asymmetry, 1992, 3, 261.

Contrasting Pathways for the Directed Homogeneous Hydrogenation of Vinylsulphoxides and

Vinylsulphones, D. Ando, C. Bevan, J.M. Brown and D.W. Price, J. Chem. Soc. Chem. Commun.,

1992, 594

170. Vinylborane Formation in Rhodium-catalysd Hydroborations; Ligand-free Homogeneous

Catalysis, J. M. Brown and G.C. Lloyd-Jones, J. Chem. Soc. Chem. Commun., 1992, 710.

Intramolecular Facilitation of Aryl-transfer from Tin in Palladium-catalysed Cross-coupling, J. M.

Brown, M. Pearson, J.T.B.M. Jastrzebski and G. Van Koten , J. Chem. Soc Chem. Commun.

1992, 1440.

Mechanistic Aspects of the Rhodium-catalysed Enantioselective Transfer Hydrogenation of

a,b-Unsaturated Acids using Formic Acid/Triethylamine (5:2) as the Hydrogen Source, W.Leitner,

J.M. Brown and H. Brunner, J. Am. Chem. Soc. 1993, 115, 152

The Stereochemistry of Enamide Intermediates in DuPHOS-Rh(I) Catalysed Asymmetric

Hydrogenation, S.K. Armstrong, J.M. Brown and M.J. Burk, Tetrahedron Lett., 1993, 34, 689

Selectivity and Mechanism in Catalytic Asymmetric Synthesis, J. M. Brown, Chemical Society

Reviews, 1993, 22, 25 [Tilden Lecture].

Preparation of Enantiomerically Pure Phosphine Oxides by Nucleophilic Displacement Chemistry

using Oxazaphospholidines, J.V. Carey, M.D. Barker, J.M. Brown and M.J.H. Russell, J. Chem.

Soc. Perkin 1, 1993, 748-57.

Synthesis and Resolution of 1-(2'-Diphenylphosphino-1'-naphthyl)isoquinoline; a P-N Chelating

Ligand for Asymmetric Catalysis. N.W. Alcock, J.M. Brown and D.I. Hulmes, Tetrahedron

Asymmetry, 1993, 4, 743-56.

Stereochemistry of the Catalysed Diels-Alder Reaction between Cyclopentadiene and Dimethyl

Monothionofumarate; Soft versus Hard Lewis Acids. D.C. Braddock, J.M. Brown and P.J. Guiry,

J. Chem. Soc. Chem. Commun., 1993, 1512.

Origins of Enantioselectivity in Catalytic Asymmetric Synthesis, J.M. Brown, P.J. Guiry and A.

Wienand "Molecular Recognition" D.A. Buckingham, D.C. Legon and S.M. Roberts, Eds,

Chapman and Hall, 1993, Ch 4, pp. 79-108.

Reversible Monomer-Dimer Equilibria in an Ephedrine-derived Oxazaborolidine, J.M. Brown, G.J.

Lloyd-Jones and T.P. Layzell, Tetrahedron : Asymmetry, 1993, 4, 2151-4

180 Effective Catalytic Asymmetric Hydroboration with the Rhodium Complex of 1-(2'-

Diphenylphosphino-1'-naphthyl)isoquinoline, J.M. Brown, D.I. Hulmes and T.P. Layzell, J. Chem.

Soc. Chem. Commun., 1993, 1673-4.

Vinylborane Formation in Rhodium-catalysed Hydroboration of Vinylarenes; Mechanism versus

Borane Structure and Relationship to Silation, J.M. Brown and G.C. Lloyd-Jones, J. Am. Chem.

Soc. 1994, 116, 866-879.

Scope of the C-S Insertion Reaction of Thiazolium Salts with Platinum [0] Diphosphine Complexes

V. C.M. Smith, R.T. Aplin, J.M. Brown, M.B. Hursthouse, A. I. Karalov and N.A. Cooley, J. Am.

Chem. Soc., 1994, 116, 5180-9.

Mechanistic and Synthetic Studies in Catalytic Allylic Alkylation with Palladium Complexes of 1-(2'-

Diphenylphosphino-1'-naphthyl)isoquinoline, J.M. Brown, D.I. Hulmes and P.J. Guiry, Tetrahedron

1994, 49, 4493-4506 (Sharpless / Noyori Tetrahedron Prize Invitation Issue).

Chirality and the Metal-alkene Bond; Distortions in the Solution and Solid-state Structures of h2-

Ethene Rhodium bis-Oxazolinylmethane Complexes, J.M. Brown, P.J. Guiry, D.W. Price, M. B.

Hursthouse and A. I. Karaulov, Tetrahedron : Asymmetry, 1994, 5, 561-4.

Bite Angle Dependence of the Rate of Reductive Elimination from Diphosphine Palladium

Complexes, J.M. Brown and P.J. Guiry, Inorg. Chim. Acta., 1994, 220, 249-60

[Invitation Volume 1994; Metals in Organic Synthesis]

A Chelating Diphosphine with a Single Stereogenic Phosphorus Atom; RP or SP-(2-

Methoxyphenyl)-P-phenyl-P-(2'-diphenylphosphino)ethylphosphine, J.A. Ramsden, J.M. Brown,

M.B. Hursthouse and A.I. Karalov, Tetrahedron : Asymmetry, 19945, 2033-44

Stable Arylpalladium Iodides and Reactive Arylpalladium Trifluoromethanesulfonates in the

Intramolecular Heck Reaction, J.M. Brown, J.J. Pérez-Torrente, N.W. Alcock and H.J. Clase,

Organometallics, 1995, 14, 207-15.

Restricted Rotation about the Metal-Aryl Bond in Platinum-aryl Complexes of Chiral Diphosphines,

J. M. Brown J. J. Pérez-Torrente and N.W. Alcock, Organometallics, 1995, 14, 1195-1203.

Contrasting Behaviour of Related Palladium Complex-derived Resolving Agents. 8-H

Conformational Locking of the 1-Naphthyl Side-chain, N.W. Alcock, D.I. Hulmes and J. M. Brown,

J. Chem. Soc. Chem. Commun., 1995, 395-7.

190 Houben-Weyl "Methodischen der Organische Chemie" E21a Stereoselective Synthesis of Organic

Compounds , J.M. Brown, Chapter 1.1.3. "Formation of C-C Bonds by Alkylation using Chiral

Additives"; Thieme Verlag, Stuttgart, 1995, G. Helmchen, Ed., pg. 1119-27.

Steric and Electronic Requirements of Amide and Ester Groups in Benzylidenemalonates J. M.

Brown, P. J. Guiry, J. C. P. Laing, M. B. Hursthouse and K. M. A. Malik, Tetrahedron, 1995, 51,

7423-34 .

Ruthenium Diphosphine Complexes for Catalysis; A General Synthesis and Direct Comparisons

with Rhodium Complexes, J. M. Brown, M. Rose, F. I. Knight and A. Wienand, Rec. Trav. Chim,

1995, 114, 242-51, (Chirality Special Issue).

Catalysts for Stereospecific Synthesis, J. M. Brown, "Speciality Inorganic Chemicals" Ch. 6., pg.

123-144, D. T. Thompson, Ed., RSC Publications, Cambridge, 1995.

Houben-Weyl "Methodischen der Organische Chemie" E21d Stereoselective Synthesis of

Organic Compounds , J.M. Brown, Chapter 2.5.1.1.1. "Directed Homogeneous Hydrogenation";.

Thieme Verlag, Stuttgart, 1995, G. Helmchen, Ed., pg. 4317-34.

Houben-Weyl "Methodischen der Organische Chemie" E21d Stereoselective Synthesis of Organic

Compounds , J.M. Brown, Chapter 2.5.1.2.4 "Enantioselective Olefin Isomerisation" Thieme

Verlag, Stuttgart, 1995, G. Helmchen, Ed., pg. 4360-4.

Catalytic Asymmetric Hydroboration with Heterotopic P-N Ligands; Trends in Enantioselectivity

with Increased Steric Demand. J- M. Valk, G. A. Whitlock, T. P. Layzell and J. M. Brown,

Tetrahedron : Asymmetry, 1995, 7, 2593-6.

Synthesis and Chemistry of a New P-N Chelating Ligand; (R) and (S)-6-(2'-Diphenylphosphino-1'-

naphthyl)phenanthridine, J-M. Valk, T. D. W. Claridge, J. M. Brown, D. Hibbs and M. B.

Hursthouse, Tetrahedron : Asymmetry, 1995, 7, 2597-2610.

Magnesium in Organic Synthesis S. K. Armstrong and J. M. Brown, "Comprehensive

Organometallic Chemistry" 2nd. Ed., A. McKillop, Ed., Volume 11, 1995, pg. 129-158.

Structure and Dynamics of Intermediates in Asymmetric Hydrogenation by Rhodium Complexes of

(2-methoxyphenyl)-P-phenyl-P-(2'-diphenylphosphino)ethylphosphine, J. A. Ramsden, T. D. W.

Claridge and J. M. Brown, J. Chem. Soc. Chem. Commun., 1995, 2469-71

200 Observation of Reactive Intermediates in Palladium-catalysed Arylation of Methyl Acrylate

(The Heck Reaction), J.M. Brown and K. K. (Mimi) Hii, Angew. Chem. Int Ed. Engl.

1996, 35, 657-9.

Synthesis and Resolution of 2,2'-bis-diphenylphosphino [3,3']biindolyl ; a New Atropisomeric

Ligand for Transition Metal Catalysis, U. Berens, J. M. Brown, J. M. Long and R. Selke,

Tetrahedron : Asymmetry, 1996, 7, 285-92.

Supports for Solid Phase Synthesis with High Fluidity and High Functionality, J. M. Brown and J.

A. Ramsden, Chem. Commun., 1996, 2117-8

Competing Nickel-catalysed Dimerisation and Degenerate Isomerisation of Propene, J. M. Brown

and G. D. Hughes, Inorg. Chim. Acta., 1996, 252, 229-237 (Invitation Issue)

Catalytic Asymmetric Hydroboration-Amination E. Fernandez, M. W. Hooper, F. I. Knight and J. M.

Brown, Chem. Commun, 1997, 173-4

Synthesis of 1-Methyl-2-diphenylphosphino-3-(1'-isoquinolyl)indole; an Easily Racemised Ligand

giving Insights into Catalytic Asymmetric Allylation, T. D. W. Claridge, J. M. Long, J. M.Brown, D.

Hibbs and M. B. Hursthouse, Tetrahedron, 1997, 53, 4035-50. (A.J. Birch Commemorative Issue,

joint Ed.).

Conformational Analysis of Phosphinamine Ligands, J. M. Brown, D.I.Hulmes, J.M. Long, J-M.

Valk, S. Pearson, D.M. Bayston, A. Goeke, J.E. Muir and N.W. Alcock, ECTOC Electronic

Conference on Trends in Organometallic Chemistry, 1997, 28.

Nucleophilic Displacement Routes to P-chiral Phosphines; the Introduction of Sterically

Encumbered Groups, J. M. Brown and J.C.P. Laing, J. Organometal Chem., 1997, 529, 435-44.

Intermediates in the Intermolecular Asymmetric Heck Arylation of Dihydrofurans, K. K. Hii, T. D.

W. Claridge and J. M. Brown, Angew. Chem. Int. Ed., 1997, 36, 984-7..

Reversible Aromatic Bromination induced by Butressing; 1-Bromo- and 8-Bromo-3,6-di-t-butyl-2-

methoxynaphthalene, D.C.Braddock, S.C.Tucker and J.M.Brown, Bull Soc. Chim. France, 1997,

134, 499-510 (Kagan Special Issue).

210. Electrophilic Amination of Catecholboronate Esters formed in the Asymmetric Hydroboration

of Vinylarenes, F.I. Knight, J. M. Brown, D. Lazzari, A. Ricci and A. J. Blacker, Tetrahedron,

1997, 53, 11411-424.

Synthesis of 1ʼ-(2-diarylphosphino)1-naphthyl)isoquinolines; variation of the aryl substituent,

H.Doucet and J. M. Brown, Tetrahedron : Asymmetry, 1997, 8, 3775-84.

Stereoselectivity in the Mass-spectral Fragmentation of Palladium Phosphinamine Complexes,

R. T. Aplin, H. Doucet, M. W. Hooper and J. M. Brown, Chem. Commun., 1997, 2097-8.

Diastereoselective Homogeneous Hydrogenations Without Direction by Substituents, E.

Farrington, M. ComesFranchini and J. M. Brown, Chem. Commun., 1998, 277-8

The Heck Olefination Reaction; A DFT Study of the Elimination Pathway, R. J. Deeth, A. Smith, K.

K. Hii and J. M. Brown, Tetrahedron Lett., 1998, 39, 3229-32

Allylic Alkylation with Function-bearing Organozinc Reagents, H. Doucet and J. M. Brown, Bull.

Soc. Chim. France, 1997, 134, 995.

Rational Models for the Carbonyl-ene Cyclization Reaction. Open and Closed Transition-states, D.

C. Braddock, K. K. Hii and J. M. Brown, Angew. Chem. Int. Ed. Engl., 1998, 37, 2113-7

Mechanism and Synthesis in Catalytic Hydroboration, J.M. Brown, H. Doucet, E. Fernandez, H.E.

Heeres, M.J. Hooper, D. I. Hulmes, F. .I. Knight, T.P. Layzell and G.C. Lloyd-Jones,

Organometallics in Synthesis” Chemistry for the 21st Century Series, Blackwellʼs, Oxford, 1999,

465-481

Hydrogenation of Function-bearing C=C bonds, J. M. Brown, in “Comprehensive Asymmetric

Catalysis” Vol 1, Springer-Verlag, Heidelberg, 1999, 60-122.

Isolation of the Reactive Intermediate in the Palladium-catalysed Coupling of Secondary

Phosphine-boranes and Aryl Iodides, A.C. Gaumont, M. B. Hursthouse, S. J. Coles, and J. M.

Brown, Chem. Commun, 1999, 63-4.

220. Hybrid P-chiral Diphosphines for Asymmetric Hydrogenation, D. Carmichael, H. Doucet and

J. M. Brown, Chem. Commun., 1999, 261-2.

The Scope of Catalytic Asymmetric Hydroboration/Oxidation with Rhodium Complexes of 1,1'-(2-

Diarylphosphino)isoquinolines, H. Doucet, E. Fernandez, T. P. Layzell and J. M. Brown,

Chemistry; Eur. J., 1999, 5, 1320-30.

Covalent Adhesion; Organic Reactivity at a Solid-solid Interface through an Inter-Bead Diels-Alder

Reaction, J. A. Ramsden, T. Z. Kovacs, I. P. Thomas and J. M. Brown, Chem. Commun., 1999,

1507-8.

Organometallic Bonding and Reactivity, Fundamental Studies; J.M. Brown and P. Hoffmann, Eds.,

Topics in Organometallic Chemistry, (Preface VII-XIV) Vol 4.Springer-Verlag, Heidelberg, 1999.

Factors affecting the Oxidative Addition of Aryl Electrophiles to1,1ʼ-Bis(diphenylphosphino)

ferrocenepalladium(η2-methyl acrylate), an Isolable Pd[0] alkene Complex. A. Jutand, K. K. Hii,

M. Thornton-Pett and J. M. Brown, Organometallics, 1999, 18, 5367-5374

Diastereoselectivity in Scalemic Tartrate /Titanium Epoxidations, J. M. Brown, S. J. Leppard, J.

Oakes and D. Thornthwaite, Chirality, 2000, 12, 496-504 (Noyori Special Issue)

Catalytic Asymmetric Hydroboration/Amination and Alkylamination with Rhodium Complexes of

1,1'-(2-Diarylphosphino-1-naphthyl)isoquinoline, E. Fernandez, K. Maeda, M. W. Hooper and J. M.

Brown, Chemistry; Eur. J., 2000, 6, 1840-1846.

Electrophilic amination routes from alkenes, E. Fernandez and J. M. Brown in "Modern Amination

methods" Ch 2., A. Ricci, Ed., Wiley-VCH, 2000, Chapter 2, pages 37-63.

Catalytic and Stoichiometric Lewis Acid Participation in Aldehyde Ene Cyclisations, D. C. Braddock

and J. M. Brown, Coll Czech. Chem. Comm., 2000, 65, 741-756(Cervinka Invitation Issue).

The Chatt-Dewar-Duncanson Model Revisited; X-ray, DFT and NMR Studies of Rhodium-Alkene

Binding. Deviations from Structural Ideality, D. W. Price, M. G. B. Drew, K. K. Hii and J. M. Brown,

Chemistry; Eur. J., 2000, 6, 4587-4596

230. Lewis Acid Mediated Type I Carbonyl Ene Cyclisations of (R)-2-Isopropyl-5-methylhex-5-enal

Access to Enantiopure Menthol Skeletons, D. C. Braddock and J. M. Brown, Tetrahedron :

Asymmetry 2000, 11, 3591-3607

PHIP Detection of a Transient Rhodium Dihydride Intermediate in the Homogeneous

Hydrogenation of Dehydroamino Acids, R. Giernoth, H. Heinrich, N. J. Adams, R. J. Deeth, J.

Bargon, J. M. Brown, J. Am. Chem. Soc., 2000, 122, 12381-12382

New Mechanistic Aspects of the Asymmetric Homogeneous Hydrogenation of Alkenes, J. M.

Brown and R. Giernoth, Current Opinion in Drug Discovery and Development, 2000, 3, 825-832

Resolution and Coupling of 1-2ʼ-Hydroxy-1ʼ-naphthyl)isoquinolines, S. C. Tucker, J. M. Brown, J.

Oakes and D. Thornthwaite, Tetrahedron, 2001, 57, 2545-2554. (Kagan Special Issue)

Interplay of Synthesis and Mechanism in Asymmetric Homogeneous Catalysis, N. J. Adams, J.

Bargon, J. M. Brown, E. J. Farrington, E. Galardon, R. Giernoth, H. Heinrich, B. D. John, K.

Maeda, Pure Appl. Chem., 2001, 73, 343-6 (XIX COMC Conference Paper)

Scope and Limitations of Ruthenium-catalysed Metathesis of Simple Polymer-bound Alkenes, P.

G. Breed, J. A. Ramsden and J. M. Brown, Can J. Chem, 2001, 79, 1049-1057.

Observation of a Stable cis-diphosphine Solvate Rhodium Dihydride derived from PHANEPHOS,

H. Heinrich, J. Bargon, R. Giernoth, J. M. Brown, Chem. Commun. 2001, 1296-1297.

The Intermolecular Asymmetric Heck Reaction; Mechanistic and Computational Studies, K. K. Hii,

T. D. W. Claridge, J. M. Brown, A. Smith and R. J. Deeth, Helv. Chim. Acta., 2001, 84, 2043-2056

(Venanzi Memorial Issue).

Origins of Asymmetric Amplification in Autocatalytic Alkylzinc Additions, D. G. Blackmond, C. R.

McMillan, S. Ramdeehul, A. Schorm and J. M. Brown, J. Am. Chem. Soc., 2001, 123, 10013-

10014.

Competing Regiochemical Pathways in the Heck Arylation of 1,2-Dihydronaphthalene, K. Maeda,

E. J. Farrington, E. Galardon, B. D. John, and J. M. Brown, Adv. Synth. Catal., 2002, 344, 104-110

240. Synthesis and Reactivity of a Ferrocene-derived Pincer Ligand, E. J. Farrington, E. Martinez

Viviente, B. S. Williams, G. van Koten and J. M. Brown, Chem. Commun, 2002, 308-309.

Nobel Prizes in Chemistry 2001; Asymmetric Hydrogenation recognised! J. M. Brown, Adv. Synth.

Catal., 2001, 343, 755-756.

Efficient Kinetic Resolution in Hydroboration of 1,2-Dihydronaphthalenes. K. Maeda and J. M.

Brown, Chem. Commun, 2002, 310-311

Ruthenium-catalysed Oxidative Heck Reactions, J. M. Brown, E. J. Farrington, C. F. J. Barnard, E.

Rowsell, Angew. Chem. Int Ed., 2002, 41, 169-171

Profound Steric Control of Reactivity in Aryl Halide Addition to Bis-Phosphine Palladium[0]

Complexes. E. Galardon, S. Ramdeehul, J. M. Brown, A. R. Cowley, K. K. (Mimi) Hii and A.

Jutand, Angew. Chem. Int. Ed., 2002, 41, 1760-1763.

The Role of Ligand Transformations on the Performance of Phosphite- and Phosphinite-Based

Palladium Catalysts in the Suzuki Reaction, R. B. Bedford, S. L. Hazelwood, M. E. Limmert, J. M.

Brown, S. Ramdeehul, A. R. Cowley, S. J. Coles and M. B. Hursthouse, Organometallics 2003,

22, 1364-1371.

Practical Preparation and Resolution of 1-(2'-Diphenylphosphino-1'-naphthyl)isoquinoline

(QUINAP), a Useful Ligand for Catalytic Asymmetric Synthesis, C-W. Lim, O. Tissot, A. Mattison,

M. W. Hooper, J. M. Brown, A. R. Cowley, D. I. Hulmes and A. J. Blacker, Org. Proc. Res. Devel.,

2003, 7, 379-384

Mechanistic and Synthetic Aspects of Hydroboration with a Simple Atropisomeric Ligand prepared

from 1-(1ʼ-isoquinolyl)-2-naphthol, A. Korostylev, I. Gridnev and J. M. Brown, J. Organometal

Chem., 2003, 680, 329-335.

Reflections on Spontaneous Asymmetric Synthesis, I. D. Gridnev, J. M. Serafimov, H. Quiney and

J. M. Brown, Org. Biomol. Chem., 2003, 1, 3811-3819.

A Direct meta-Lithiation Route to 1,3-Disubstituted Ferrocenes, C. Pichon, B. Odell and J. M.

Brown, Chem. Commun., 2004, 598-9.

250. Asymmetric Autocatalysis; Novel structures; novel mechanism? I. D. Gridnev and

J. M. Brown, Proc. Natl. Acad US, 2004, 101, 5727-5731.

Electronic Control of the Regiochemistry in Palladium-Phosphine Catalyzed Intermolecular Heck

Reactions. R. J. Deeth, A. Smith and J. M. Brown, J. Am.Chem. Soc. 2004, 126, 7144-7151

Conformationally Restricted Arene Intermediates in the Intermolecular Heck Arylation of

Vinylarenes, K. K. (Mimi) Hii, T. D. W. Claridge, R. Giernoth and J. M. Brown, Adv. Syn. Catal.

2004, 346, 983-8.

Mechanism in Homogeneous Catalysis; NMR as a Prime Mover. J. M. Brown, J. Organomet.

Chem., 2004, 689, 4006-4015 [JOMC 40th Anniversary Issue.]

Solution Structure and Reagent Binding of the Zinc Alkoxide Catalyst in Soaiʼs Asymmetric

Autocatalytic Reaction, I. D. Gridnev, J. M. Serafimov and J. M. Brown, Angew. Chem. Int. Ed.,

2004, 43, 4884-4888.

Rhodium(I)-Catalyzed Hydroborations and Related Reactions, Ch 2., pages 33-53, J. M. Brown in

"Recent Advances in Rhodium-Catalyzed Transformations" P. A. Evans, Ed; John Wiley and

Sons, NY, 2005.

Ruthenium-complex Catalysed Heck Reactions of Areneboronic Acids, Mechanism, Synthesis and

Halide Tolerance, E. J. Farrington, C. F. J. Barnard, E. Rowsell and J. M. Brown, Adv. Syn. Catal.

2005, 347, 185-195.

Acetato[1-(oxazolin-2-ylmethyl-kN)indol-2-yl](triphenylphosphine)palladium(II) dichloromethane

solvate, A. R. Cowley, R. I. Cooper, E. Capito, J. M. Brown and A. Ricci, Acta Cryst. E, 2005, 61,

m582- m584.

Chloro 1-[(dimethylamino)methyl- N]-1H-indolyl- C2 (triphenylphosphine- P)palladium(II)

dichloromethane solvate. R. I. Cooper, A. R. Cowley, E. Capito, J. M. Brown and A. Ricci Acta

Cryst. E, 2005, 61, m585- m586.

Imidazo[1,5-a]pyridine: A Versatile Architecture for Stable N-Heterocyclic Carbenes, M. Alcarazo,

S. J. Roseblade, A. R. Cowley, R. Fernandez, J. M. Brown, and J. M. Lassaletta, J. Am. Chem.

Soc., 2005, 127, 3290-3292.

260 Directed palladation: fine tuning permits the catalytic 2-alkenylation of indoles, E. Capito, J.

M. Brown and A. Ricci, Chem. Commun. 2005, 1746-1748.

Synthesis, Structure and Dynamics of Methoxynaphthalene-substituted Phospha-ruthenocenes

and –ferrocenes, D. Carmichael, L. Ricard, N. Seeboth, J. M. Brown, T. D. W. Claridge, B.

Odell, Dalton Trans., 2005, 2173-2181

Regiochemical control of the catalytic asymmetric hydroboration of 1,2-diarylalkenes, A. Black,

J. M. Brown, and C. Pichon, Chem. Commun. 2005, 5284-5286.

Mechanism of Asymmetric Hydrogenation, J. M. Brown, “Handbook of Homogeneous

Hydrogenation” C. Elsevier and J. H. G de Vries, ed., John Wiley and Sons, New York, 2006; vol

3, pages 1073-1100

trans-Bromido[4,5-difluoro-2(trifluoromethylsulfonyloxy)phenyl-C1]bis(triphenylphosphine-

P)palladium (II), G. Espino, J. M. Brown and A. R. Cowley, Acta Cryst. 2007, E63, m2047-m2048.

Aryl bromide/triflate selectivities reveal mechanistic divergence in palladium-catalysed couplings;

the Suzuki-Miyaura anomaly. G. Espino, A. Kurbangalieva and J. M. Brown, Chem. Commun.,

2007,1742-1744.

Role of the isopropyl group in asymmetric autocatalytic zinc alkylations, J. Klankermayer, I. D.

Gridnev, J. M. Brown, Chem. Commun. 2007, 3151-3153.

The Guareschi Reaction (1897). Alkyl Radical Generation in Water under Ambient Conditions, B.

Nguyen, J. M. Brown, K. Chernous, D. Endlar, B. M. Odell, M. Piacenti, A. S. Dorofeev and A. V.

Burasov. Angew. Chem. Int. Ed., 2007, 46, 7655-7658.

A Protocol for the Direct Conversion of Aldehydes to Arenes; Proof of Principle, M. Gayral and J.

M. Brown, Synlett, 2007, 2823-2826.

New Paracyclophane Phosphine for Highly Enantioselective Ruthenium-Catalyzed Hydrogenation

of Prochiral Ketones, M. N. Cheemala, M.Gayral, J. M. Brown, K. Rossen and P. Knochel,

Synthesis, 2007, 3877-3886.

270 Crabtreeʼs Catalyst Revisited: Ligand Effects on Stability and Durability, Y. Xu,

D. M. P. Mingos and J M. Brown, Chem Commun, 2008, 199-201.

Asymmetric Autocatalysis with Organozinc Complexes; Elucidation of the Reaction Pathway, I.

D.Gridnev, J. Klankermayer, J. M. Brown, Topics Current Chem., 2008, 284, 35-65; K. Soai, Ed.

Sequential ortho-Lithiations; the Sulfoxide group as a Relay to enable meta-Substitution, J. P.

Flemming, M. B. Berry and J. M. Brown, Org. Biomol. Chem., 2008, 1215-1221.

Catalytic Amide-mediated Methyl Transfer from Silanes to Alkenes in Fujiwara-Moritani Oxidative

Coupling, W. Rauf and J. M. Brown, Angew. Chem. Int. Ed., 2008, 47, 4228-4230.

Synthesis and Rhodium Complexation of Enantiomerically Pure Bicyclo[3.3.1]nona-2,6-diene

M. Mayr, C. J. R. Bataille, S. Gosiewska, J. A. Raskatov and J. M. Brown, Tetrahedron:

Asymmetry, 2008, 19, 1328-1332.

Enantiomerically pure bicyclo[3.3.1]nona-2,6-diene as the sole source of enantioselectivity in

BIPHEP-Rh asymmetric hydrogenation, T. Punniyamurthy, M. Mayr, A. Dorofeev, C. J. R. Bataille,

S. Gosiewska, B. Nguyen, J. M. Brown, Chem. Commun., 2008, 5092-5094.

Tetrameric Iridium Hydride-rich Clusters formed under Hydrogenation Conditions, Y. Xu, M. A.

Celik, A. L. Thompson, H. Cai, M. Yurtsever, B. Odell, J. C. Green, D. M. P. Mingos, and J. M.

Brown, Angew. Chem. Int. Ed., 2009, 48, 582-5.

Allylic Fluorides are Responsive to Palladium-catalysed Substitution, A. Hazari, V. Gouverneur, J.

M. Brown, Angew. Chem. Int. Ed., 2009, 48, 1296-1299.

Stereoselectivity in the Rhodium-catalysed Reductions of Non-conjugated Dienes, B. Nguyen, J.

M. Brown, Adv. Syn. Catal. 2009, 351, 1333-1343.

Disubstituted Benzenes from Acyclic Precursors by a [5 + 1] Route, D. S. B. Daniels, J. M. Brown,

M. Gayral, Y. Xu and M. I. Stewart, Synlett, 2009, 1387-1390.

280 Is Enantioselectivity Predictable in Asymmetric Catalysis? J. M. Brown and R. J. Deeth,

Angew. Chem. Int. Ed., 2009, 48, 4476-4479.

Comparative Catalytic C-H vs. C-Si Activation of Arenes with Pd Complexes Directed by Urea or

Amide Groups, W. Rauf, A.L. Thompson and J. M. Brown, Chem. Commun. 2009, 3874-3876.

Transition Metal Mediated Reactions for sp2 C-F Bond Construction: the State of Play. J. M. Brown

and V.Gouverneur, Angew. Chem. Int. Ed., 2009, 48, 8610-8614.

Catalytic Amide-directed Palladadesilylation Alkenylation, W. Rauf and J. M. Brown, Synlett, 2009,

3103-3106.

Observation of 2,7-Disubstitution in Palladium-catalysed Directed C-H Activation of Indoles, G.

Fanton, N. R. Coles, J. P. Flemming and J. M. Brown, Heterocycles, 2010, 895-901. (Special Issue

for Suzukiʼs 80th birthday).

Catalytic activation of hydrogen, silicon and fluorine by transition-metal complexes, W. Rauf, A.

Hazari, V. Gouverneur and J. M. Brown, Pure. Appl. Chem. 2010, 82,1415-1428.

Asymmetric catalysis with 7-ring chelate diphosphines: DIOP, BINAP and conformational mobility,

J. A. Raskatov, A. L. Thompson and J. M. Brown, Tetrahedron: Asymmetry, 2010, 21, 1734-1740.

Unusual Inverse Temperature Dependence on Reaction Rate in the Autocatalytic Alkylation of

Pyrimidyl Aldehydes, M. Quaranta, T. Gehring, B. Odell, J. M Brown, and D. G. Blackmond, J.

Amer. Chem. Soc., 2010, 132, 15104-15107.

Anilide Activation of Adjacent C-H Bonds in the Palladium-catalysed Fujiwara-Moritani Reaction,

W. Rauf, A. L. Thompson and J. M. Brown, Dalton Trans., 2010, 39,10414-10421. .

Hydroboration and Diboration of Alkenes, Stereoselective Synthesis 1.7 Science of Synthesis, B.

N. Nguyen and J. M. Brown, Thieme; 2010 pg 295-324.

290 Palladium-Catalyzed Allylic Fluorination, C. Hollingworth, A. Hazari, M. N. Hopkinson,

M. Tredwell, E. Benedetto, M. Huiban, A. D. Gee, J. M. Brown, and V. Gouverneur,

Angew. Chem.-Int. Ed., 2011, 50, 2613-2617.

Chiral selection in the formation of borates from racemic binaphthols and related diols J. A. Raskatov, J. M. Brown, and A. L. Thompson, Crystengcomm, 2011, 13, 2923-2929.

Electrophilic Routes to Tertiary Adamantyl and Diamantyl Phosphonium salts, J. Prabagar, A. R.

Cowley and J. M. Brown, Synlett, 2011, 2351-2354 (A. Ricci Special Issue).

The Origins of Enantioselectivity in Rh-diene Complex Catalysed Arylation of Cyclohex-2-enones.

S. Gosiewska, J. A. Raskatov, R. Shintani, T. Hayashi, J. M. Brown, Chem.- Eur. J., 2012, 18, 80-84.

Platinum-catalysed Substitution of Allyl Fluorides, E. Benedetto, M. Keita, M. Tredwell,

C.Hollingworth, J. M. Brown and V. Gouverneur, Organometallics, 2012, 31, 1408-1416.

Palladium-Catalyzed Substitution and Cross-Coupling of Benzylic Fluorides, G. Blessley, P.

Holden, M. Walker, J. M. Brown and V. Gouverneur, Org. Lett., 2012, 11, 2754-2757.

Dinuclear Palladium Complexes – Precursors or Catalysts? R. S. Paton and J. M. Brown, Angew.

Chem.-Int. Ed., 2012, 51, 10448-10450.

Observation of a Transient Intermediate in Soaiʼs Asymmetric Autocatalysis: New Insights

from 1H NMR Turnover in Real Time, T. Gehring, M. Quaranta, B. Odell, D. G. Blackmond and J.

M. Brown, Angew. Chem.-Int. Ed., 2012, 51, 9539-9542.

Regio- and Stereoretentive Synthesis of Branched, Linear, (E)- and (Z)-Allyl Fluorides from Allyl

Carbonates under Ir-Catalysis, E.Benedetto, M. Tredwell, C. Hollingworth, T. Khotavivattana, J. M. Brown and V. GouverneurChem. Sci. 2013, 4, 89-96.

Patents

"Surface active material useful as catalyst in two-phase reactions", J. M. Brown and J. A. Jenkins

(to NRDC) Brit 1,579,320, 19 Nov 1980; Appl. 75/49,666

"Asymmetric Hydroboration", UK Patent Application 93 23 028.2; J. M. Brown, Nov 1993

“Preparation of optically active alcohols and amines by asymmetric hydroboration, using chiral

[(diphenylphosphino)naphthyl]isoquinoline complex catalysts”, J. M. Brown,. PCT Int. Appl.

(1995), 37 pp. WO 9513284.

Supports for Solid-Phase Synthesis with High Fluidity and High Functionality” UK Patent

Application, J.M. Brown and J.A. Ramsden, October 1996

Preparation of diphosphines as cocatalysts for asymmetric hydrogenation. J. M. Brown; D.

Carmichael; H. Doucet, PCT Int. Appl. (2000), WO 2000026220, 21 pp.

Preparation of metal phosphine catalysts as pure enantiomers starting from enantiomerically pure

dienes, J. M. Brown, M. Mayr; UK Patent Application (2006).

Dr J.M. Brown

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Chemistry Research Laboratory

john.brown@chem.ox.ac.uk

Telephone: 44 (0) 1865 275 642

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