Research Guides

Department of Chemistry University of Oxford

Professor J.R. Dilworth

Biomedical, catalytic and materials applications of coordination chemistry

Jon Dilworth was an undergraduate student at Jesus College, Oxford and then in 1967 went to the University of Sussex for a DPhil with Professor J. Chatt at the Unit of Nitrogen Fixation. He stayed at Sussex until 1985 (DSc 1981) when he moved to take the Chair of Chemistry at the University of Essex. In 1997 he moved to his current position in Oxford.

Positron Emission Tomographic image of a copper-64 complex in a rat

Jon Dilworth’s research focusses on applications of coordination chemistry in biomedicine, catalysis and materials. The biomedical research is directed to the development of new imaging and therapeutic agents based on complexes of technetium, rhenium and copper radioisotopes. The copper based programme synthesises new radioactive complexes for use in imaging hypoxia to improve treatments for cancer. The materials research aims to make new metal sulphur complexes as precursors for binary sulphides with novel electronic properties and suitable for use as engine oil additives. The catalysis work is directed to making novel metal-based catalysts with sulphur co-ligands.

The Dilworth group uses the full range of conventional instrumentation available in the new Chemistry Research Laboratory and has two laboratories there. In addition a new radiochemical facility will be opened in October 2006 with hot cells capable of handling both gamma and positron emitting radioisotopes.

Collaborations are ongoing with the Department of Radiation, Oncology and Biology at the Churchill Hospital Oxford, the Gray Cancer Institute, Wolfson Brain Imaging Centre, Cambridge, Department of Clinical Pharmacology, Oxford, and Department of Chemistry, University of Zurich. There are industrial links with Infineum UK, GE(Healthcare), GSK  and Siemens Molecular Imaging

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