The broad goal of our research is the generation of externally-controllable nucleic acids (EC-NAs) under the control of various stimuli, including temperature, magnetism, and light. This approach will enable the control of multiple DNA and RNA-based technologies.
We are currently developing EC-NAs to control synthetic cells, lipid-bounded compartments containing a cell-free protein expression system inside them, for controllable and targeted drug delivery. These synthetic cells will be able to deliver a large variety of molecules, from small molecule drugs to large biomacromolecules.
We are also implementing EC-NAs to control other technologies including gene editing and silencing, molecular machines, and aptamers.
Work with us
If you are interested in joining our interdisciplinary team as a Part II, DPhil, or postdoctoral researcher please contact Dr Booth directly.
- Light-patterning of synthetic tissues with single droplet resolution (2017) M.J.Booth, V.Restrepo-Schild, S.Box, H.Bayley. Scientific Reports. 7, 9315.
- Functional aqueous droplet networks (2017) M.J.Booth, V.Restrepo-Schild, F.Downs, H.Bayley. Molecular Biosystems. 13, 1658-1691.
- Light-activated communication in synthetic tissues (2016) M.J.Booth, V.Restrepo-Schild, A.D.Graham, S.N.Olof, H.Bayley. Science Advances. 2 (4), e1600056.
- Chemical methods for decoding cytosine modifications in DNA (2015) M.J.Booth, E.Raiber, S.Balasubramanian. Chemical Reviews. 115 (6), 2240-2254.
- Quantitative sequencing of 5-formylcytosine in DNA at single-base resolution (2014) M.J.Booth, E.Raiber, S.Balasubramanian. Nature Chemistry. 6 (5), 435-440.
- Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution (2012) M.J.Booth, M.R.Branco, G.Ficz, D.Oxley, F.Krueger, W.Reik, S.Balasubramanian. Science. 336 (6083), 934.