Research Guides

 

Research Summary

Our research revolves around the design of novel methodologies for detection and analysis of magnetic resonance (NMR, EPR, MRI, and in vivo MRS) spectroscopic data. In collaboration with researchers from a wide range of disciplines (chemists, biologists, mathematicians, physicists, computer scientists, and spectroscopists), we aim at a holistic approach in magnetic resonance method development and the applications of these technologies to real problems in chemical and medical research including the study of structures, reactions, and dynamics of small and large molecules.

 

Current research interests in our group include: 

i) To design ultrahigh-resolution MR techniques for the study of small molecules, pharmaceuticals, and biomolecules.

ii) To design ultra-broadband radiofrequency and microwave pulses and on-the-fly optimization of NMR and EPR experiments, especially drawing on numerical methods like derivative-free optimization techniques and optimal control theory.

iii) To design novel optically-detected MR spectroscopy and imaging techniques with ultra-high spectral and spatial resolution using super-sensitive quantum sensors like nitrogen vacancies in diamonds, and to explore applications of these devices for the study of chemicals, living tissues, and surfaces at a cellular and molecular level.

iv) To develop signal processing tools for spectral estimation and analysis of MR spectra and images, especially using model-selection techniques, non-linear optimization, and computational learning theory.

 

For more information please visit our Research Group Website.

 

Selected Publications

13. A visible-light photoactivatable di-nuclear PtIV triazolato azido complex
Yao, K.; Bertran, A.; Howarth, A.; Goicoechea, J.M.; Hare, S.M.; Rees, N.H.; Foroozandeh, M.; Bowen, A.; Farrer, N.J.
Chem. Commun. 2019, in press
DOI: 10.1039/C9CC05310G

12. Improved ultra-broadband chirp excitation
Foroozandeh, M.; Nilsson, M.; Morris, G.A.
J. Magn. Reson. 2019, 302, 28-33
DOI: 10.1016/j.jmr.2019.03.007

11. PSYCHE Pure Shift NMR Spectroscopy
Foroozandeh, M.; Morris, G. A.; Nilsson, M.
Chem. Eur. J. 2018, 24, 1-14
DOI: 10.1002/chem.201800524

10. Ultrahigh-Resolution Diffusion-Ordered Spectroscopy
Foroozandeh, M.;Castanar, L.; Martins, L. G.; Sinnaeve, D.; Dal Poggetto, G.; Tormena, C. F.; Adams, R. W.; Morris, G. A.; Nilsson, M.
Angew. Chem. Int. Ed. 2016, 55, 50, 15579-15582
DOI: 10.1002/ange.201609676

9. A General Method for Extracting Individual Coupling Constants from Crowded 1H NMR Spectra
Sinnaeve, D; Foroozandeh, M.; Nilsson, M.; Morris, G. A.
Angew. Chem. Int. Ed. 2016, 55, 1090-1093
DOI: 10.1002/anie.201508691

8. Very broadband diffusion-ordered NMR spectroscopy: 19F DOSY
Power, J. E.; Foroozandeh, M.; Moutzouri, P; Adams, R. W.; Nilsson, M.; Coombes, S. R.; Phillips, A. R.; Morris, G. A.
Chem. Commun. 2016, 52, 6892-6894
DOI: 10.1039/c6cc02917e

7. Increasing the quantitative bandwidth of NMR measurements
Power, J. E.; Foroozandeh, M.; Adams, R. W.; Nilsson, M.; Coombes, S. R.; Phillips, A. R.; Morris, G. A.
Chem. Commun. 2016, 52, 2916-2919
DOI: 10.1039/c5cc10206e

6. Measuring couplings in crowded NMR spectra: pure shift NMR with multiplet analysis
Foroozandeh, M.; Adams, R. W.; Kiraly, P.; Nilsson, M.; Morris, G. A.
Chem. Commun. 2015, 15410-15413
DOI: 10.1039/C5CC06293D

5. Flaws in foldamers: conformational uniformity and signal decay in achiral helical peptide oligomers
Bryden Le Bailly, Liam Byrne, Vincent Diemer, Mohammadali Foroozandeh, Gareth A Morris and Jonathan Clayden
Chem. Sci. 2015
DOI: 10.1039/C4SC03944K

4. Ultrahigh-Resolution Total Correlation NMR Spectroscopy
Foroozandeh, M., Adams R.W., Nilsson M., Morris G.A.
J. Am. Chem. Soc. 2014
DOI: 10.1021/ja507201t

3. Ultrahigh-Resolution NMR Spectroscopy
Foroozandeh, M., Adams R.W., Meharry N.J., Jeannerat D., Nilsson M., Morris G.A.
Angew. Chem. Int. Ed. 2014, 53, 6990-6992
DOI: 10.1002/anie.201404111

2. Diastereomeric Ratio Determination by High Sensitivity Band-Selective Pure Shift NMR Spectroscopy
R.W. Adams, L. Byrne, P. Kiraly, M. Foroozandeh, L. Paudel, M. Nilsson, J. Clayden, and G.A. Morris
Chem. Commun. 50 (2014), 2512
DOI: 10.1039/C3CC49659G

1. Simultaneously Enhancing Spectral Resolution and Sensitivity in Heteronuclear Correlation NMR Spectroscopy
Paudel, Liladhar; Adams, Ralph W.; Kiraly, Peter; Aguilar, Juan A.; Foroozandeh, Mohammadali; Cliff, Matthew J.; Nilsson, Mathias; Sandor, Peter; Waltho, Jonathan P.; Morris, Gareth A.
Angew. Chem. Int. Ed. 2013
DOI: 10.1002/anie.201305709

 

Dr Mohammadali Foroozandeh

Royal Society University Research Fellow

Chemistry Research Laboratory,

12 Mansfield Road,
Oxford,
OX1 3TA
 
Office: S1 (2nd floor, room 1)
Telephone: 44 (0) 1865 272 634

mohammadali.foroozandeh@chem.ox.ac.uk

 

Research Group Website

http://research.chem.ox.ac.uk/mohammadali-foroozandeh.aspx