10 Selected publications
Kukwikila, M., Gale, N., El-Sagheer, A. H., Brown, T. & Tavassoli, A. Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation. Nature Chem., doi:10.1038/NCHEM.2850 (2017).
Hardwick, J. S. et al. 5-Formylcytosine does not change the global structure of DNA. Nature Struct. Mol. Biol., doi:10.1038/nsmb.3411 (2017).
Shivalingam, A., Tyburn, A. E. S., El-Sagheer, A. H. & Brown, T. Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation. J. Amer. Chem. Soc. 139, 1575–1583 (2017).
Haugland, M. M. et al. 2 '-Alkynylnucleotides: A Sequence- and Spin Label-Flexible Strategy for EPR Spectroscopy in DNA. J. Amer. Chem. Soc. 138, 9069-9072, (2016).
Meng, W. et al. An Autonomous Molecular Assembler for Programmable Chemical Synthesis. Nature Chem. 8, 542-548 (2016).
Harimech, P. K., Gerrard, S. R., El-Sagheer, A. H., Brown, T. & Kanaras, A. G. Reversible Ligation of Programmed DNA-Gold Nanoparticle Assemblies. J. Amer. Chem. Soc. 137, 9242-9245, (2015).
El-Sagheer, A. H., Sanzone, A. P., Gao, R., Tavassoli, A. & Brown, T. Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in E. coli. Proc. Natl. Acad. Sci. USA 108, 11338–11343, (2011).
El-Sagheer, A.H., Brown, T. New strategy for the synthesis of chemically modified RNA constructs exemplified by hairpin and hammerhead ribozymes. Proc. Natl. Acad. Sci. USA 107, 15329-15334, (2010).
El-Sagheer, A. H. & Brown, T. Synthesis and Polymerase Chain Reaction Amplification of DNA Strands Containing an Unnatural Triazole Linkage. J. Amer. Chem. Soc. 131, 3958-3964, (2009).
Whitcombe, D., Theaker, J., Guy, S. P., Brown, T. & Little, S. Detection of PCR products using self-probing amplicons and fluorescence. Nature Biotechnol. 17, 804-807 (1999).