Research Guides

Department of Chemistry University of Oxford

Professor Stephen P. Fletcher

Our research group is especially interested in developing new catalytic asymmetric reactions to rapidly access complex molecules from simple starting materials. We have discovered a series of copper and rhodium catalysed asymmetric addition reactions and we are involved in studying the mechanisms of these reactions and applying the methods in the synthesis of important targets. 

We are also working to uncover how the most basic functions of living systems can be observed in purely synthetic systems by learning how to generate far-from-equilibrium self-replicators and mimicking engineering strategies seen in biology, with the long-term goal of understanding what is different about living and non-living matter. 

Please visit our Research Group Website for further information. 

An asymmetric Suzuki-Miyaura approach to prostaglandins: Synthesis of Tafluprost. Org. Let. 2020, 22, 2991.  Link

Selection from a pool of self-assembling lipid replicators. Nature Comm. 2020, 11, 176.  Link

Retooling asymmetric conjugate additions for statically demanding substrates with an iterative data-driven approach. ACS Catalysis 2019, 9, 1011.  Link

A chemically fuelled self-replicator. Nature Comm. 2019, 10, 1011.  Link

Enantio- and diastereoselective Suzuki-Miyaura coupling with racemic bicycles. Angew. Chem. Int. Ed. 2019, 10, 1011.  Link

Molecular machines for catalysis. Nature Rev. Chem. 2018, 2, 0117.  Link

Transmission of chirality through space and across length scales. Nature Nanotech. 201712, 410-419. Link

Rhodium-catalysed asymmetric allylic arylation of racemic halides with arylboronic acids. Nature Chem. 20157, 935-939. Link

Non-stabilized nucleophiles in Cu-catalysed dynamic kinetic asymmetric allylic alkylation. Nature 2015517, 351–355. Link

Conversion of light into macroscopic helical motion. Nature Chem. 2014, 6, 229-235. Link