Research Guides

Professor T.J. Donohoe

Organic Chemistry

Telephone: 44 (0) 1865 275 649

Research Group Web Pages

Group News 

March 2021. Congratulations to Bruno Marinic and Elliot Bailey who recently received commendations for their PRS transfer reports and vivas.
December 2020. A DPhil studentship is available in the TJD group, starting in October 2021. The project involves developing new catalytic chemistry to directly functionalise aromatic rings, via temporary dearomatisation, and is funded by the EPSRC and GSK (iCASE). For more details see:
April 2020, well done to CB, Simon and James: their latest communication on hydrogen borrowing and in situ vinyl cyclopropane ring expansion is designated as a HOT paper in Angewandte Chemie.
November 2019, well done to Lewis Smith for gaining a commendation after his PRS transfer report and viva.
November 2019, Post-doc position. An EPSRC funded post-doc position is available in the group for two years with the possibility of extension. The project is centred around hydrogen borrowing. See
jobs.aspx?ID=1288 for details and how to apply. Closing date is 9th December.

September 2019, well done to Ben Reeves, Hamish Hepburn and Alex Grosavu- their latest work on dearomative functionalisation was accepted in Angewandte Chemie. This is Tim's 200th paper.

August 2019, congratulations to two TJD group part II students for winning prizes for their theses: Dana Ayenetdinova (Brian Bannister Prize and GSK Prize) and Benjamin Reeves (Organic Chemistry and Chemical Biology Runners-up Prize).

May 2019 well done to Max Haughey for winning a prize in the AstraZeneca sponsored final-year DPhil talks.

March 2019 A paper on the synthesis of lamellarins D and Q has been accepted in Chemical Science; well done to Harry, Maria and Filip.

March 2019 Well done to team 'Shawshank Reduction' who recently gained second place in the RSC/SCI retrosynthesis competition. The team comprosed of Tim Kwok, Ciaran Lunt, Daniya Aynetdinova (TJD group) and Mihai Popescu (MDS group).

February 2019 Congratulations to Dr Roly Armstrong who won a prize for his talk given at the Departmental Syngenta Postdoc Symposium.

October 2018 A paper from the group has been accepted in Nature Chemistry; well done to Alex, Hamish and Philip.

July 2018 Congratulations to Filip Muncan for winning a Part-II thesis runner-up prize.

November 2017 Congratulations to Timothy Kwok for winning a Lilly prize for Excellence in Organic Chemistry Research.

October 2017 Well done to Wasim Akhtar for winning one of the prizes in the AZ sponsored final year DPhil talks.

February 2017 Well done to Wasim, CB and James: their latest JACS communication on hydrogen borrowing was accepted.

October 2016 Congratulations to Simon Werrel for winning a prize in the AstraZeneca sponsored DPhil Final Year Talks.

July 2016 Part II students in the TJD group have recently won undergraduate prizes: congratulations to Max Haughey for winning a Brian Bannister thesis prize and to Jack Hoffman for winning a thesis runner-up prize.

June 2016 Kate Melikhova's paper on the synthesis and structural revision of the microsclerodermins was recently accepted for publication in Angewandte Chemie.

Ignacio's paper in collaboration with Richard Compton is accepted in JACS.

October 2015 Congratulations to Kate Melikhova who has recently completed the syntheses of two complex natural products, microsclerodermin J and dehydromicrosclerodermin B.

November 2014 Congratulations to three DPhils: Simon Werrel, who has been awarded a Lilly Prize for Excellence in Organic Chemistry Research, and Johannes Walker, who received a commendation, for their first year work. Congratulations also to Sandra Balcells-Garcia who has been awarded a Senior Cheetham Scholarship from Brasenose College

October 2014 Tim has given his 200th external research lecture since appointment in 1994.

October 2014 Tim has been appointed as one of the editors of the journal Tetrahedron Letters, starting on 1st Jan 2015. A postdoctoral editorial assistant position is available, see:

July 2014 Congratulations to Camilla Shotton who received the Bannister Prize for the best organic chemistry Part II thesis.

July 2014 A paper on work done by Di Shen and Louis Chan (in collaboration with Mark Howarth, Biochemistry) was chosen as a cover image by Bioorganic and Medicinal Chemistry.

May 2014 Tim has been awarded the 2014 Charles Rees Award by the Royal Society of Chemistry. The award is given biennially to recognise excellence in heterocyclic chemistry. Tim will give an award lecture at the RSC Lakeland Symposium in Grasmere in 2015.

April 2014 Tim has been awarded a 5 year EPSRC Established Career Fellowship: PDRA positions will be available in the near future, see the Departmental website for details.

March 2014 A DPhil position is available in the Donohoe group; please contact me for details. NOW FILLED.

December 2013 A recent paper by Chris and Anne on first and second generation synthesis routes to the anti-tumour compound Streptonigrin, was selected by J. Org. Chem as a Featured Article.

November 2013 A new paper by Louis, Darren and Di on ketone methylation using methanol was selected by Angewandte Chemie as a Hot Paper. Images from the paper were also selected for the Angewandte cover.

October 2013 Congratulations to Kate Melikhova (2nd year DPhil), who has recently been awarded one of the Lilly Prizes for Excellence in Organic Chemistry Research for her first year work.

July 2013 Congratulations to Johannes Walker (part II student), who has recently been awarded a Departmental prize for the quality of his part II thesis.

July 2013 Congratulations to Kate Melikhova (1st year DPhil), who has recently been awarded a scholarship by the SCI.

April 2013 A postdoc position, funded by EPSRC, is available in the group, to start on or soon after 01/06/2013. Please see:

March 2013 Jobs! many congratulations to Rob Pullin who has recently been offered a job as a medicinal chemist at Vertex, and to Ben Pilgrim who will take up a Herchel Smith Postdoctoral Research Fellowship at the University of Cambridge in conjunction with a Fellowship at Corpus Christi College; also to Chris Jones who was recently awarded an independent Ramsay Memorial Fellowship to be held at Queen Mary, University of London.

December 2012 Radek Lipinski's paper on the synthesis of the ABC ring system of pectenotoxin-4 is designated as a Hot Paper in Angewandte Chemie.

November 2012 Congratulations to Matthew Tatton (3rd year DPhil) who was recently awarded a Syngenta sponsored Scientific Scholarship.

August 2012 Tim has won the 2012 AstraZeneca, GlaxoSmithKline, Pfizer & Syngenta Prize for Process Chemistry Research. The award will be presented at the forthcoming 30th SCI Process Development Symposium held in Cambridge between 5th-7th December. Tim will receive a trophy and a cheque for £16000 to support further research.

February 2012 Congratulations to Christian Winter and Robert Pullin, who along with David Daniels (Ed Andersen group) were winners of the SCI's 1st National Retrosynthesis Competition. Ten teams, from both academia and industry, were selected for the final, which was held on 29th February at the SCI, London. Their presentation of the retro- and forward synthesis of Alsmaphophorazine E, was judged overall winner of the competition

October 2011 Well done to Ben Pilgrim, a third year DPhil student who was awarded a poster prize at the Organic Chemistry Poster Symposium held in the CRL. Ben’s poster was entitled the ‘Palladium-Catalyzed Synthesis of Isoquinolines’.

September 2011 Congratulations to Ben Pilgrim, a third year DPhil student who has been awarded a poster prize at the 26th Postgraduate Symposium of the RSC Heterocyclic and Synthesis Group. The symposium was held at the AstraZeneca site at Alderley Edge on 22nd September. Ben’s poster was entitled the ‘Palladium-Catalyzed Synthesis of Isoquinolines’.

September 2011 Congratulations to Chris Jones who has recently completed the synthesis of streptonigrin in 14 linear steps and 11% overall yield. This work was recently accepted for publication in J. Am. Chem. Soc

July 2011 Congratulations to Alice Gatland who has been awarded one of the Departmental Thesis Prizes for her Part II thesis entitled A novel hydride shift approach to the synthesis of spiroketals.

May 2011 Tim has been awarded the 2011 Synthetic Organic Chemistry Award by the Royal Society of Chemistry. The prize is given for the development of new methods or strategies employed in the construction of organic molecules. The prize will be presented at a symposium held later in the year.

More news can be found here.


Our research interests are in catalysis and synthetic organic chemistry, and the contribution that they can make to the fields of medicine and natural products. We concentrate on developing new catalytic methodologies for synthetic organic chemistry and asymmetric synthesis and then employing our chemistry to make biologically important natural products.

Our work is directly relevant to the pharmaceutical industry and the research group is (or has been) supported by multi-national companies including Merck, AstraZeneca, GlaxoSmithKline, Lilly, Novartis, Roche, Aventis and Pfizer. The facilities available for research in our labs in the CRL are second to none.

The research group consists of four part II’s, twelve DPhil students and four postdoctoral assistants. We meet two/three times per week to discuss advances in the laboratory and hold problem sessions to highlight recent developments in the literature.

We are an active and vibrant research group with a positive dynamic and friendly atmosphere. Excellent support is given to new part II’s and DPhil students in the form of mentorship by a senior group members. Our research interests are wide ranging, encompassing osmium-catalysed processes, Birch reduction of pyrroles and pyridinium salts, carbohydrate chemistry and catalytic ring closing metathesis as a strategy for the formation of aromatic heterocycles. With each new catalytic method that we develop, we are also keen to show that it is useful in total synthesis. In this regard, the group has built up significant expertise in the synthesis of natural products; some of our current targets are shown below.

Hydrogen Borrowing: recently we have become active in the area of hydrogen borrowing because it is a powerful catalytic method for C-C and C-N bond formation which only produceds water as a waste product. Initial work concentrated on the role that methanol can play in enolate alkylation, while more recent studies have developed the pentamethylbenzene (Ph*) group as an incredibly powerful and versatile substituent for hydrogen borrowing alkylation.

Oxidation: One research theme is the controlled oxidation of alkenes with catalytic osmium reagents. Our work on the tethered aminohydroxylation of allylic carbamates has encompassed an understanding of the mechanism and introduced a new set of N-O based re-oxidants into the catalytic aminohydroxylation regimen (the result is a much more powerful and high yielding aminohydroxylation procedure). This methodology allowed us to prepare the aminocyclitol (-)-hygromycin in a particularly efficient manner. Our work culminated in a completion of the synthesis of the natural product in only 17 linear steps (and 10% overall yield) by using a Mitsunobu glycosylation that allowed the formation of the difficult glycoside linkage with good stereoselectivity.

Our investigations into the osmium catalysed formation of THFs and pyrrolidines from diols and aminoalcohols, revealed the advantages of utilising the Os(IV)-(VI) couple, avoiding the presence of Os(VIII). We also uncovered an OMs displacement/ hydride shift sequence, followed by intramolecular trapping of the oxonium ion to form a trans-THF (supported by deuterium labelling). The combination of double oxidative cyclisation and a hydride shift was used in the synthesis of the natural products (+)-cis-sylvaticin and (+)-sylvaticin.

Partial Reduction We have a longstanding interest in developing the partial reduction of aromatic heterocycles using single electron reducing agents such as (catalytic) LiDBB. Our work has been able to reduce pyrroles, pyridines and furans in a selective and high yielding manner, and the heterocycles that are prepared via this chemistry have lots of potential for natural (and medicinal) product synthesis. In fact, each of these aromatic ring systems has been used as the starting point in the synthesis of complex and biologically active natural products.

By studying the mechanism using cyclic voltammetry (with R. G. Compton) we have  been able to understand the processes that take place and design new arenes for partial reduction, thus allowing greater scope for synthetic work.

Publications (>200 publications; those so far since 2011 are shown below; full list available here).
1) Osmium-free direct syn-dihydroxylation of alkenes, Carole J. R. Bataille and Timothy J. Donohoe, Chem. Soc. Rev. 2011, 40, 114-128.
2) Recent Developments in Methodology for the Direct Oxyamination of Olefins, Timothy J. Donohoe, Aida Flores, Cedric K.A. Callens, Adam J. Lacy, Akshat H. Rathi, Chem. Eur. J., 2011, 17, 58-76.
3) Heteroaromatic Synthesis via Olefin Cross-Metathesis: Entry to Polysubstituted Pyridines, Timothy J. Donohoe, José Basutto, Akshat H. Rathi and John F. Bower, Organic Letters, 2011, 13, 1036-1039.
4) Palladium nanoparticle-modified carbon nanotubes for electrochemical hydrogenolysis in ionic liquids, Yao Meng, Leigh Aldous, Ben S. Pilgrim, Timothy J. Donohoe and Richard G. Compton, New Journal of Chemistry, 2011, 35, 1369-1375.
5) Exerting Control over the Acyloin Reaction, Timothy J. Donohoe, Ali Jahanshahi, Michael J. Tucker, Farrah L. Bhatti, IshmaelA. Roslan, Mikhail Kabeshov and Gail Wrigley, Chemical Communications, 2011, 47, 5849-5851.
6) Dehydrogenation of Cyclic-Thioethers Bound to a [Rh(diphosphine)]+ Fragment, Romeao Dallanegra, Ben S. Pilgrim, Adrian B. Chaplin, Timothy J. Donohoe and Andrew S. Weller, Dalton Transactions, 2011, 40, 6626-6628.
7) A short and efficient synthesis of neodysiherbaine A using catalytic oxidative cyclisation, Timothy J. Donohoe, Paul Winship, Matthew R. Tatton and Peter Szeto, Angewandte Chemie, Int. Ed. 2011, 50, 7604-7606.
8) Intramolecular Hydride Addition to Pyridinium Salts: New Routes to Enantiopure Dihydropyridones, Timothy J. Donohoe, Matthew J. Connolly, Akshat H. Rathi and Lesley Walton, Organic Letters, 2011, 13, 2074-2077.
9) The Influence of Exocyclic Stereochemistry on the Tethered Aminohydroxylation Reaction, Timothy J. Donohoe, Adam R. Lacy, Akshat H. Rathi, and Daryl S. Walter, Chemistry: An Aisian Journal, 2011, 6, 3214-3222.
10) Surface plasmon resonance imaging of glycoarrays identifies novel and unnatural carbohydrate-based ligands for potential ricin sensor development, Margherita Fais, Rositsa Karamanska, Sarah Allman, Shirley A. Fairhurst, Paolo Innocenti, Antony J. Fairbanks, Timothy J. Donohoe, Benjamin G. Davis, David A. Russell and Robert A. Field, Chemical Science, 2011, 2, 1952.
11) Tethered aminohydroxylation, Timothy J. Donohoe and Stefanie Mesch, Asymmetric Synthesis – The Essentials II. Edited by Mathias Christmann and Stefan Brase, WILEY-VCH, 2011, in the press.
12) Synthesis of 2,4,6-Trisubstituted Pyridines via an Olefin Cross-Metathesis/Heck-Cyclisation-Elimination Sequence, Timothy J. Donohoe, John F. Bower, David B. Baker,José A. Basutto, Louis K. M. Chan and Peter Gallagher, Chemical Communications, 2011, 47, 10611.
13) Amino acid based reoxidants for aminohydroxylation: application to the construction of amino acid-aminoalcohol conjugates, Timothy J. Donohoe, Cedric K. A. Callens, Aida Flores, Stefanie Mesch, Darren L. Poole and Ishmael A. Roslan, Angewandte Chemie Int Ed., 2011, 50, 10957.
14) Total Synthesis of (±)-Streptonigrin: De-novo Construction of a Pentasubstituted Pyridine using Ring Closing Metathesis, Timothy J. Donohoe, Christopher Jones and Luiz Claudio Barbosa, J. Am. Chem. Soc., 2011, 133, 16418.
15) Improvements in the Tethered Aminohydroxylation Reaction and its Application to Total Synthesis, Timothy J. Donohoe, Cedric K. A. Callens, Adam R. Lacy, Christian Winter, European Journal of Organic Chemistry, 2012, 643-650 (plus cover picture for this issue).
16) Direct Preparation of thiazoles, imidazoles, imidazopyridines and thiazolidines from alkenes, Timothy J. Donohoe, Mikhail Kabeshov, Akshat Rathi and Ian E. D. Smith, Org. Biomol. Chem., 2012, 10, 1093-1101.
17) Olefin Cross-Metathesis for the Synthesis of Heteroaromatic Compounds, Timothy J. Donohoe, John F. Bower and  Louis K. M. Chan, Organic and Biomolecular Chemistry, 2012, 10, 1322-1328. Designated as a Hot Article.
18) Hydrogen-Bonding-Mediated Directed Osmium Dihydroxylation, Timothy J. Donohoe,* Carole J. R. Bataille, Paolo Innocenti, Organic Reactions 2012, 76, 1-47.  ISBN:978-0-470-63843-9.
19) A green approach to Fenton chemistry: Hydroxylation of salicylic acid in aqueous medium using electrogeneration of Fenton's Reagent. J. Panchompoo, L. Aldous, R. G.Compton, M. Kabeshov, B. Pilgrim, T. J. Donohoe, New. J. Chem. 2012, 36, 1265.
20) Synthesis of substituted isoquinolines utilizing palladium-catalyzed α-arylation of ketones, T. J. Donohoe, B. S. Pilgrim, G. R. Jones, J. A. Bassuto, Proc Natl Acad Sci USA, 2012, 109, 11605-11608.
21) Natural Product Synthesis as a Challenging Test of Newly Developed Methodology, T. J. Donohoe, R. Pullin, Chemical Commun. 2012, 48, 11924-11938.
22) Asymmetric Synthesis of the Fully Elaborated Pyrrolidone Core of Oxazolomycin A, T. J. Donohoe, T. J. C. O'Riordan, M. Peifer, C. R. Jones, T. J. Miles, Organic Lett. 2012, 14, 5460-5463.
23) Partial and complete reduction of pyrroles, furans, thiophenes and their benzo-analogues and of aromatic heterocycles containing more than one heteroatom, Timothy J. Donohoe,* Christopher Jones and Christian Winter, Comprehensive Organic Synthesis II , Ed. G. Molander and P. Knochel, Elsevier, 2013, in the press.
24) Oxidative cyclisation for the synthesis of complex THF-containing natural products, Timothy, J. Donohoe, R. D. C. Pullin, Radoslaw M. Lipinski, Pure & Applied Chem. 2013, 85, 1175-1184.
25) Interplay of cascade oxidative cyclisation and hydride shifts in the synthesis of the ABC spiroketal ring system of pectenotoxin-4, T. J. Donohoe, R. M. Lipinski, Angewandte Chemie, 2013, 52, 2491-2494. Designated as a HOT paper.
26) Osmium-Catalyzed Oxidative Cyclization of Dienes and their Derivatives, Timothy J. Donohoe* and Ben Pilgrim, Journal of Organic Chemistry, 2013, 78, 2149-2167. Work from this paper featured in the cover picture for JOC.
27) Vinyl Weinreb Amides: A Versatile Alternative to Vinyl Ketone Substrates for Heck Arylation, David Baker, Peter Gallagher and Timothy J. Donohoe,* Tetrahedron, 2013, 69, 3690-3697.
28) Lithium-4,4'-Di-tert-butylbiphenylide, Christopher R. Jones and Timothy J. Donohoe, Encyclopedia of Reagents for Organic Synthesis, 2013, in the press.
29) Tethered Aminohydroxylation: Synthesis of the β Amino Acid of Microsclerodermins A and B, Robert Pullin, Akshat Rathi, Ekaterina Melikhova, Christian Winter, Amber Thompson and Timothy J. Donohoe, Organic Letters, 2013, 15, 5492-5495.
30) Modular isoquinoline synthesis using catalytic enolate arylation and in-situ functionalization, Ben Pilgrim, Alice Gatland, Charlie McTernan, Panayiotis Procopiou, Timothy Donohoe, Organic Letters, 2013, 15, 6190-6193.
31) Total Synthesis of the Antitumor Antibiotic (+/-)-Streptonigrin: First and Second Generation Routes for de-novo Pyridine Formation using Ring Closing Metathesis, Timothy Donohoe, Christopher Jones, Anne Kornahrens, Luiz Barbosa, Louise Walport, Matthew Tatton, Michael O'Hagan, Akshat Rathi, David Baker, J. Org. Chem. 2013, 78, 12338-12350. Selected as a Featured Article.
32) Rhodium-Catalyzed Ketone Methylation Using Methanol Under Mild Conditions: Formation of Alpha-Branched Products, Louis K. M. Chan, Darren L. Poole, Di Shen, Mark P. Healy and Timothy J. Donohoe, Angewandte Chemie Int. Ed., 2014, 53, 761-765. Designated as a HOT paper.
33) De novo Synthesis of Multi-Substituted Aryl Amines using Alkene Cross Metathesis, Matthew Tatton, Iain Simpson and Timothy J. Donohoe, Organic Letters, 2014, 16, 1920-1923.
34) Love–Hate ligands for high resolution analysis of strain in ultra-stable protein/small molecule interactions, M. Fairhead, D. Shen, L. K. M. Chan, E. D. Lowe, T. J. Donohoe, M. Howarth, Bioorganic and Medicinal Chemistry, 2014, 22, 5476-5486.
35) New methods for the synthesis of naphthyl amines; application to the synthesis of dihydrosanguinarine,  sanguinarine, oxysanguinarine and maclekarpines B and C, Matthew R. Tatton, Iain Simpson, Timothy J. Donohoe, Chemical Communications, 2014, 50, 11314-11316.
36) Short and efficient syntheses of protoberberine alkaloids using palladium catalyzed enolate arylation, Alice E. Gatland, Ben S. Pilgrim, Panayiotis A. Procopiou and Timothy J. Donohoe, Angewandte Chemie Int. Ed., 2014, 53, 14555-14558.
37) Hydrogen borrowing and interrupted hydrogen borrowing reactions of ketones and methanol, catalysed by iridium, Di Shen, Darren L. Poole, Camilla C. Shotton, Anne F. Kornahrens, Mark P. Healy and Timothy J. Donohoe, Angewandte Chemie Int. Ed., 2015, 54, 1642-1645.
38) Palladium-catalyzed alpha-arylation of carbonyls in the de novo synthesis of aromatic heterocycles, Harish K. Potukuchi, Anatol P. Spork and Timothy J. Donohoe, Organic and Biomolecular Chemistry, 2015, 13. 4367-4373.
39) Modular Synthesis of Highly Substituted Pyridines via Enolate α-Alkenylation, Leo Hardegger, Jacqueline Habegger, Timothy J. Donohoe, Organic Letters, 2015, 17, 3222-3225.
40) Application of Catalytic Z-selective Olefin Metathesis in Natural Product Synthesis, Simon Werrel, Johannes Walker, Timothy J.  Donohoe, Tetrahedron Letters, 2015, 56, 5261-5268.
41) Aziridine electrophiles in the functionalisation of peptide chains with amine nucleophiles, Anatol P. Spork, Timothy J. Donohoe, Organic and Biomolecular Chemistry, 2015, 13, 8545-8549.
42) Strategic application and transformation of ortho-di-substituted phenyl and cyclopropyl ketones to expand the scope of hydrogen borrowing catalysis, James R. Frost, Choon Boon Cheong, Wasim M. Akhtar, Dimitri F. J. Caputo, Neil G. Stevenson and Timothy J. Donohoe, J. Am. Chem. Soc. 2015, 137, 15664-15667.
43) Palladium-catalysed enolate arylation as a key C-C bond forming reaction for the synthesis of isoquinolines, Ben S. Pilgrim, Alice E. Gatland, Carlos H. A. Estaves, Charlie T. McTernan, Geraint R. Jones, Matthew R. Tatton, Panayiotis A. Procopiou, Timothy J. Donohoe, Organic and Biomolecular Chemistry, 2016, 14, 1065-1090.
44) Catalytic hypervalent iodine promoters allow styrene dimerisation and the formation of tri- and tetrasubstituted cyclobutanes, Ignacio Colomer, Rosimeire Coura Barcelos and Timothy J. Donohoe, Angewandte Chemie Int. Ed., 2016, 55, 4748-4752.
45) Synthesis of aromatic heterocycles using ring-closing metathesis, Harish K. Potukuchi, Ignacio Colomer, Timothy J. Donohoe, in E. F  V. Scriven and C. A. Ramsden, editors, Advances in Heterocyclic Chemistry: Heterocyclic Chemistry in the 21st Century: A tribute to Alan Katritzky, Elsevier, 2016, pp 43-65.
46) Dehydromicrosclerodermin B and microsclerodermin J: total synthesis and structural revision, Ekaterina Y. Melikhova, Robert D. C. Pullin, Christian Winter, Timothy J. Donohoe, Angewandte Chemie Int. Ed., 2016, 55, 9753-9757.
47) Hydrogen bonding to hexafluoroisopropanol controls the oxidative strength of hypervalent iodine reagents, Ignacio Colomer, Christopher Batchelor-McAuley, Barbara Odell, Timothy J. Donohoe, Richard Compton, J. Am. Chem. Soc. 2016, 138, 8855-8861.
48) Orthogonally protected 1,2 diols from electron-rich alkenes using metal free olefin syn dihydroxylation, Ignacio Colomer, Rosimeire Coura Barcelos, Kirsten E. Christensen, Timothy J. Donohoe, Organic Letters, 2016, 18, 5880-5883.
49) Iridium-Catalyzed C4-Alkylation of 2,6-Di-tert-butylphenol using Hydrogen Borrowing Catalysis, James R. Frost, Choon Boon Cheong, Timothy J. Donohoe, Synthesis, 2017, 49, 910-916.
50) Diastereoselective synthesis of the 5-hydroxy-pyrrolidinone amino acid of the microsclerodermins and model studies for an end-game strategy for microsclerodermin B, Christian Winter, Robert D. C. Pullin and Timothy J. Donohoe, Tetrahedron Letters, 2017, 58, 602-605.
51) Hydrogen borrowing catalysis with secondary alcohols: a new route for the generation of β-branched carbonyl compounds, Wasim Akhtar, Cheong Choon Boon, James Frost, Kirsten Christensen, Neil Stevenson and Timothy J. Donohoe, J. Am. Chem. Soc. 2017, 139, 2577-2580.
52) Catalytic enolate arylation with 3-bromoindoles allows the formation of beta-carbolines, C. Henrique Estaves, Christopher Hall, Peter Smith, Timothy .J Donohoe, J. Org. Chem. 2017, 82, 4435-4443.
53) Pyruvate enolate arylation and alkylation:OBO ester protected pyruvates as useful reagents in organic synthesis, C. Henrique Estaves, Christopher Hall, Peter Smith, Timothy J. Donohoe, Organic Letters, 2017, 19, 5248-5251.
54) Hexafluoroisopropanol as a highly versatile solvent, Ignacio Colomer, Anna Chamberlain, Maxwell Haughey, Timothy J. Donohoe, Nature Chem Rev. 2017, 1, 0088.
55) Cobalt versus osmium: control of both trans and cis stereoselectivity in construction of the EFG rings of pectenotoxin 4, Ahria Roushanbakhti, Yifan Liu, Paul M. Winship, Michael . Tucker, Wasim M. Akhtar, Daryl S. Walter, Gail Wrigley, Timothy . Donohoe, Angew. Chem. Int. Ed. 2017, 56, 14883-14887.
56) The efficacy of the quertin analogue LY294002 in immortalized cancer cell lines is related to the oxygenic and metabolic status of cells, Xinyue Huang, Michelle Potter, Ben Pilgrom, Ruchuta Ardkhean, Mikail Kabeshov, Timothy Claridge, Matthew Wiseman, Karl J. Morten, Timothy J. Donohoe, Helen E. Townley, Int. J. Cancer Ther. Oncol. 2017, 5, 51X. 
57) Asymmetric Total Synthesis of (-)-(3R)-Inthomycin C, Sandra Balcells, Maxwell B. Haughey, Johannes C. L. Walker, Laia Josa-Cullere, Christopher Towers, Timothy J. Donohoe, Organic Letters, 2018, 20, 3583-3586.
58) OBO-protected pyruvates as reagents for the synthesis of functionalized heteroaromatic compounds, C. Henrique Alves Estavez, Maria Koyioni, Kirsten E. Christensen, Peter D. Smith, Timothy J. Donohoe, Organic Letters, 2018, 20, 4048-4051.
59) Stereoselective synthesis of cyclohexanes via an iridium catalysed (5+1) annulation strategy, Wasim M. Akhtar, Roly J. Armstrong, James R. Frost, N. G. Stevenson, Timothy J. Donohoe, J. Am. Chem. Soc. 2018, 140, 11916-11920.
60) The reductive C3 functionalization of pyridinium and quinolinium salts through iridium catalysed interrupted transfer hydrogenation, Alex Grozavu, Hamish B. Hepburn, Philip J. Smith, Harish K. Potukuchi, Peter J. Lindsay-Scott, Timothy, J. Donohoe, Nature Chemistry, 2019, 11, 242-247. 
61) Synthesis of Lamellarin alkaloids using orthoester masked alpha keto acids, Harry J. Shirley, Maria Koyioni, Filip Muncan, Timothy J. Donohoe, Chem. Sci. 2019, 10, 4434-4338.
62) HFIP solvent enables alcohols to act as alkylating agents in stereoselective heterocyclisation, Yuxiang Zhu, Ignacio Colomer, Timothy J. Donohoe, J. Am. Chem. Soc. 2019, 141, 6489-6493.
63) Rhodium-catalysed vinyl 1,4-conjugate addition coupled with Sharpless asymmetric dihydroxylation in the synthesis of the CDE ring fragment of pectenotoxin 4, Melodie Richardson, Darren Poole, Christopher Tame, Timothy J. Donohoe, Chem. Sci. 2019, 10, 6336-6340.
64) Catalytic asymmetric synthesis of cyclohexanes by hydrogen borrowing annulations, Roly J. Armstrong, Wasim M. Akhtar, Tom A. Young, Fernanda Duartes, Timothy. J. Donohoe, Angewandte Chemie Int Ed. 201958, 12558-12562. Designated as a HOT paper.
65) Hypervalent iodine initiated intramolecular alkene dimerization: a stereodivergent entry to cyclobutanes, Yuxiang Zhu, Ignacio Colomer and Timothy J. Donohoe, Chemical Communications, 2019, 55, 10316-10319.
66) Photochemical alkene isomerisation for the synthesis of polysubstituted furans and pyrroles under neutral conditions, Johannes C. L. Walker, Simon Werrel and Timothy J. Donohoe, Chemistry: A European Journal, 2019, 25, 13114-13118. 
67) 1-(4-Methyl-2,6,7-trioxabicyclo[2.2.2]oct-1-yl)-ethane, Christopher Hall and Timothy J. Donohoe, Encyclopedia of Reagents for Organic Synthesis, 2019, ISBN 9780470842898. 
68) Transition metal free reductive hydroxymethylation of isoquinolines, Benjamin M. Reeves, Hamish B. Hepburn, Alex Grozavu, Peter J. Lindsay-Scott, Timothy J. Donohoe, Angewandte Chemie Int Ed. 2019, 58, 15697-15701.
69) Stereoselective synthesis of alicyclic ketones: a hydrogen borrowing approach, Roly J. Armstrong, Wasim M. Akhtar, James R. Frost, Kirsten E. Christensen, Neil G. Stevenson, Timothy J. Donohoe, Tetrahedron, 2019, 75, 130680. Steve Davies honor issue.
70) The reductive hydroxymethylation of 4-heteroarylpyridines, Hamish B. Hepburn, Timothy J. Donohoe, Chemistry: A  European Journal, 2020, 26, 1963-1967.
71) Chemo- and regioselective synthesis of acyl cyclohexenes by a tandem acceptorless dehydrogenation [1,5]-hydride shift cascade, Lewis B. Smith, Roly J. Armstrong, Timothy J. Donohoe, J. Am. Chem. Soc. 2020, 142, 2514-2523.
72) A hydrogen borrowing annulation strategy for the stereocontrolled synthesis of saturated aza-heterocycles, Anna E. R. Chamberlain, Kieran J. Paterson, Roly J. Armstrong, Heather C. Twin, Timothy J. Donohoe, Chemical Communications, 2020, 56, 3563-3566,
73) Enantioconvergent alkylation of ketones with racemic secondary alcohols via hydrogen borrowing catalysis, Daniella M. J. Cheang, Roly J. Armstrong, Wasim M. Akhtar, Timothy J Donohoe, Chemical Communications, 2020, 56, 3543-3546.
74) Control of absolute stereochemistry in transition metal catalysed hydrogen borrowing reactions, Timothy Kwok, Oskar Hoff, Roly J. Armstrong, Timothy J. Donohoe, Chemistry: A European Journal, 2020, in the press,  
75) A vinyl cyclopropane ring expansion and iridium catalysed hydrogen borrowing cascade, Simon Wubbolt, Choon Boon Cheong, James Frost, Kirsten Christensen, Timothy J, Donohoe, Angewandte Chemie. Int. Ed. 2020, 132, 11435-11440. Designated as a HOT paper; highlighted in Synfacts. 
76) A Heck reaction/photochemical alkene isomerisation sequence to prepare functionalised quinolines, Alex Kelly, Jack B. Hoffman, Oskar Hoff, Johannes C. L. Walker, Simon Werrel, Timothy J. Donohoe,  Tetrahedron, 2020, 76, 131396, Richard Taylor honor issue.
77) Rhodium catalysed C3/5 methylation of pyridines using temporary dearomatisation, Alexandru Grozavu, Hamish B. Hepburn, Elliot P. Bailey, Peter J. Lindsay-Scott, Timothy J. Donohoe, Chemical Science, 2020, 11, 8595-8599.
78)  Pentamethylphenyl (Ph*) and related derivatives as useful acyl protecting groups for organic synthesis, C. B. Cheong, James R. Frost, Timothy J. Donohoe, Synlett, 2020, 31, 1828.
79) Single point activation of pyridines enables reductive hydroxymethylation, Bruno Marinic, Hamish B. Hepburn, Alexandru Grosavu, Mark Dow, Timothy J. Donohoe, Chemical Science, 2021, 12, 742.
80) Hydrogen borrowing alkylation of 1,2-amino alcohols in the synthesis of enantioenriched gamma-aminobutyric acids, Christopher J. J. Hall, William R. F. Goundry, Timothy J. Donohoe, Angewandte Chemie. Int. Ed. 2021, 133, in the press.
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